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2009 Fiscal Year Self-evaluation Report

Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinases

Research Project

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Project/Area Number 19109004
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionKeio University

Principal Investigator

OKADA Yasunori  Keio University, 医学部, 教授 (00115221)

Project Period (FY) 2007 – 2011
KeywordsMMP / ADAM / ノックアウトマウス / 浸潤 / 転移 / 変形性関節症 / ヒアルロン酸 / 創傷治癒
Research Abstract

本研究課題では、MMP(matrix metalloproteinase)とADAM(a disintegrin and metalloproteinase)遺伝子ファミリーメンバーのうち、特にMMP-7、MMP-13、ADAMTS4、ADAM28の各分子を中心にして、以下の4研究項目について研究している。
(研究1).MMPとADAMの相互作用分子探索とADAM28遺伝子欠損(KO)マウスの開発
(研究2).癌の生物像を規定する組織内微小環境因子代謝機構の解析
(研究3).組織の破壊・増殖・改築を伴う非腫瘍性疾患での組織内微小環境因子代謝機構の解析
(研究4).MMPとADAMを標的とした診断・治療法開発の基礎的研究

  • Research Products

    (6 results)

All 2009 2008 2007 Other

All Journal Article (3 results) Presentation (1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009

    • Author(s)
      Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
    • Journal Title

      Am. J.Pathol 175

      Pages: 533-546

  • [Journal Article] Purification of matrix metalloproteinases by column chromatography.2008

    • Author(s)
      Imai, K., Okada Y.
    • Journal Title

      Nat Protoc 3

      Pages: 1111-1124

  • [Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007

    • Author(s)
      Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S., Okada Y.
    • Journal Title

      J.Biol. Chem. 282

      Pages: 25864-25874

  • [Presentation] ADAMs in tumor growth and progression.2009

    • Author(s)
      Okada Y.
    • Organizer
      In Gordon Research Conference on MMPs
    • Place of Presentation
      Invited speaker
    • Year and Date
      20090830-20090904
  • [Book] Kelley's Textbook of Rheumatology2009

    • Author(s)
      Okada Y.
    • Total Pages
      115-134
    • Publisher
      Elsevier Saunders
  • [Remarks]

    • URL

      http://keio-okada-lab.jp/

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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