Regulatory mechanism of synaptic function by actin and its role in higher brain function

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19200029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Gunma University
• Principal Investigator: SHIRAO Tomoaki Gunma University, 大学院・医学系研究科, 教授 (20171043)
• Project Period (FY): 2007 – 2010
• Keywords: シナプス形態形成 / アクチン / ドレブリン / 神経細胞培養 / 行動分析 / シナプス機能

Research Abstract

「樹状突起スパイン内アクチン結合蛋白の量的・質的動態」と「神経伝達物質受容体や足場蛋白のシナプス後部への集積」との双方向性の制御を分子レベルで解析し、アクチンによるシナプス機能制御のメカニズムを明らかにする。そして、このメカニズムの破綻がもたらすシナプス機能不全及び高次脳機能障害を、遺伝子変換マウスを用いて解析することにより、当該メカニズムの高次脳機能における役割を明らかにする。

Research Products

• [Journal Article] Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood (2010)
  • Author(s): Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T.
  • Journal Title: Neuroscience 165 Pages: 138-150
  • Peer Reviewed
• [Journal Article] AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin (2009)
  • Author(s): Takahashi, T, Yamazaki, H, Hanamura K, Sekino Y, Shirao T
  • Journal Title: J Cell Sci. 122 Pages: 1211-1229
  • Peer Reviewed
• [Journal Article] Drebrin E is involved in the mechanism regulating axonal growth through actin-myosin interactions (2009)
  • Author(s): Mizui T., Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T.
  • Journal Title: J Neurochem 109 Pages: 611-622
  • Peer Reviewed
• [Journal Article] Expression of drebrin E in migrating neuroblasts in adult rat brain : coincidence between drebrin E disappearance from cell body and cessation of migration (2008)
  • Author(s): Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T.
  • Journal Title: Neuroscience 152 Pages: 670-682
  • Peer Reviewed
• [Journal Article] Drebrin A content correlates with spine head size in the adult mouse cerebral cortex (2007)
  • Author(s): Kobayashi, C., Aoki, C., Kojima, N., Yamazaki, H., Shirao, T.
  • Journal Title: J. Comp. Neurol. 503 Pages: 618-626
  • Peer Reviewed
• [Presentation] Regulation of dendritic spine morphology by changing drebrin-A dynamics (2009)
  • Author(s): Shirao, T., Hanamura, K., Takahashi, H., Mizui, T., Sekino, Y.
  • Organizer: 21th ISN Biennial Meeting
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-23