2010 Fiscal Year Final Research Report
Actin-dependent regulation of synapse function and its role in higher brain fuction
| Project/Area Number |
19200029
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Gunma University |
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Principal Investigator |
SHIRAO Tomoaki 群馬大学, 大学院・医学系研究科, 教授 (20171043)
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| Co-Investigator(Kenkyū-buntansha) |
SEKINO Yuko 国立医薬品食品衛生研究所, 薬理部, 研究員 (70138866)
YASUDA Hiroki 群馬大学, 大学院・医学系研究科, 准教授 (60294071)
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| Project Period (FY) |
2007 – 2010
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| Keywords | シナプス / アクチン / ドレブリン / ノックアウト / LTP / グルタミン酸受容体 |
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| Research Abstract |
We used primary neuronal cell culture and knockout mice, and showed that the expression levels of spinal actin-binding proteins are related to the synaptic function, such as synaptic strength and plasticity. Then we analyzed the dynamics of spinal accumulation of actin-binding proteins, and found that glutamatergic fibers regulate the accumulation bi-directionally using two subtypes of glutamate receptors.
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[Journal Article] F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse2010
Author(s)
Perez-Martinez M, Gordon-Alonso M, Cabrero JR, Barrero-Villar M, Rey M, Mittelbrunn M, Lamana A, Morlino G, Calabia C, 山崎博幸, 白尾智明, Vazquez J, Gonzalez-Amaro R, Veiga E, Sanchez-Madrid F.
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Journal Title
J. Cell Sci.
Volume: 123
Pages: 1160-1170
Peer Reviewed
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