Evolution of drinking mechanism from aquatic to terrestrial habitat : Exploring its origin using fishes

2009 Fiscal Year Final Research Report

• Project/Area Number: 19207005
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEI Yoshio The University of Tokyo, 海洋研究所, 教授 (10129249)
• Co-Investigator(Kenkyū-buntansha): ANDO Masaaki 広島大学, 総合科学部, 准教授 (10100976) ; SAKAMOTO Tatsuya 岡山大学, 自然科学研究科, 准教授 (10294480)
• Project Period (FY): 2007 – 2009
• Keywords: 浸透圧調節 / 飲水行動 / ホルモン / 水生動物 / 脳内神経回路

Research Abstract

In this study, we found that guanylin, adrenomedullin and relaxin form a family of diversified members in teleost fishes and play important roles in osmoregulation, particularly in seawater adaptation. We also found that natriuretic peptides that suppress drinking and angiotensin that induces drinking act on the area postrema in the medulla oblongata to regulate reflex swallowing in aquatic fishes, which is in contrast to terrestrial animals where they regulate thirst by acting on the forebrain.

Research Products

• [Journal Article] Central and peripheral cardiovascular actions of adreno-medullin 5, a novel member of the calcitonin gene-related peptide family, in mammals (2008)
  • Author(s): Takei, Y, Hashimoto, H., Inoue, K., Osaki, T., Yoshizawa-Kumagaye, K., Watanabe, T. X., Minamino, N., Ueta, Y.
  • Journal Title: J. Endocrinol. 197 Pages: 391-400
  • Peer Reviewed
• [Journal Article] Exploring novel hormones essential for seawater adaptation in teleost fish (2008)
  • Author(s): Takei, Y.
  • Journal Title: Gen. Comp. Endocrinol. 157 Pages: 3-13
  • Peer Reviewed
• [Journal Article] 'reverse' phylogenetic approach for identification of novel osmoregulatory and cardiovascular hormones invertebrates (2007)
  • Author(s): Takei, Y., Ogoshi, M., Inoue, K. A
  • Journal Title: Frontiers Neuroendocrinol. 28 Pages: 143-160
  • Peer Reviewed
• [Presentation] Multiple guanylins and their receptors in the eel assume their important roles in seawater adaptation (2009)
  • Author(s): Takei, Y, Yuge, S., Ando, M.
  • Organizer: Sixteenth International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong.
  • Year and Date: 20090622-20090626
• [Presentation] Exploring essential seawater-adapting hormones in fish (2008)
  • Author(s): Takei, Y, Tsukada, T., Yuge, S., Ogoshi, M., Inoue, K.
  • Organizer: Sixth International Symposium on Fish Endocrinology
  • Place of Presentation: Calgary, Canada
  • Year and Date: 20080622-20080627
• [Presentation] Evolutionary history of the CGRP family in vertebrates (2007)
  • Author(s): Takei, Y., Ogoshi, M.
  • Organizer: Sixth International Symposium on the CGRP family
  • Place of Presentation: San Diego, USA.
  • Year and Date: 20071031-20071102
• [Book] The gastrointestinal tract as an endocrine, paracrine and autocrine organ. In : Fish Physiology Vol. 30 : The Multifunctional Gut of Fish (M. Grosell, A. P. Farrell, and C. J. Brauner) (2010)
  • Author(s): Takei, Y., Loretz, C. A.
  • Publisher: Academic Press(in press)
• [Book] Molecular and functional evolution of the adrenomedullin family in vertebrates : What do fish studies tell us? In : The Calcitonin Gene-Related Peptide Family : Form, Function and Future Perspectives. (Eds. D. L. Hay and I. Dickerson) (2009)
  • Author(s): Takei, Y., Ogoshi, M., Wong, M. K., Nobata, S.
  • Total Pages: 1-21
  • Publisher: Springer Verlag
• [Book] The neuroendocrine regulation of fluid intake and fluid balance. In : Fish Physiology, Vol. 28 : Fish Neuroendo- crinology (Eds. N. Bernier, G. Van Der Kraak, A. P. Farrell and C. J. Brauner) (2009)
  • Author(s): Takei, Y., Balment, R. J.
  • Total Pages: 365-419
  • Publisher: Academic Press, Academic Press
• [Remarks] ホームページ等
  • URL: http://physiol.ori.u-tokyo.ac.jp/seiri/