2009 Fiscal Year Final Research Report
Crosstalk among cells and molecules during bone regeneration
| Project/Area Number |
19209057
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAGUCHI Akira Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (00142430)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUBE Ken-Ichi 東京医科歯科大学, 医歯学総合研究科, 講師 (20233760)
KSAKAMOTO Kei 東京医科歯科大学, 医歯学総合研究科, 助教 (00302886)
TAMAMURA Yoshihiro 東京医科歯科大学, 医歯学総合研究科, 特任助教 (70431963)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨芽細胞 / 破骨細胞 / BMP / Notch / CCN3 / 口腔癌 |
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| Research Abstract |
We conducted experiments to elucidate cellular and molecular crosstalk during bone regeneration, and the following results were demonstrated. 1) Notch signal regulates osteoblast differentiation and bone formation, 2) CCN3 expression was greatly increased during bone regeneration, and CCN3 regulated osteoblast differentiation by crosstalk with BMP and Notch signals, 3) Crosstalk among oral cancer cells, fibroblastic cells interfacing bone surface and osteoclasts plays important roles in bone destruction by oral cancer. 4) Latexin is involved in chondrocyte differentiation during bone development and regeneration through BMP-Sox9 cascade, 5) BMP signaling is involved in pathobiology of sunovialchondromatosis.
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Author(s)
Kayamori K, Sakamoto K, Nakashima T, Takayanagi T, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
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Journal Title
Amer J Pathol 176
Pages: 968-980
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[Journal Article] CCN3 and bone marrow cells2009
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Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A
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J Cell Commun Signal 3
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[Journal Article] Enhancement of the Notch receptor signaling pathway by Cripto-12009
Author(s)
Watanabe K, Nagaoka T, Lee J, Bianco C, Gonzales M, Castro NP, Rangel MC, Sakamoto K, Youping S, Callahan R, Salomon DS
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J Cell Biol 187(3)
Pages: 343-53
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[Journal Article] E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro2008
Author(s)
Matsuda N, Katsube K, Mikami S, Katsuki Y, Iseki H, Mukai M, Yamaguchi A, Takano Y, Nakajima T, Nakajima H, Kishi K
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J Dermatol Sci 52
Pages: 21-30
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[Journal Article] Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function2007
Author(s)
Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T
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Journal Title
Mol Biol Cell 18
Pages: 2411-2418
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[Journal Article] A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor2007
Author(s)
Kabasawa Y, Katsube K, Harada H, Nagumo K, Terasaki H, Perbal B, Okada N, Omura K
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 103
Pages: 677-682
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