2009 Fiscal Year Final Research Report
Long-term molecular epidemiological studies on thyroid cancers around Chernobyl
| Project/Area Number |
19256003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMASHITA Shunichi Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (30200679)
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| Co-Investigator(Kenkyū-buntansha) |
OHTSURU Akira 長崎大学, 大学病院, 准教授 (00233198)
TAKAMURA Noboru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30295068)
NAKASHIMA Masahiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50284683)
MITSUTAKE Norisato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50404215)
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| Project Period (FY) |
2007 – 2009
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| Keywords | チェルノブイリ / 小児甲状腺がん / 分子疫学調査 / がん組織バンク / 癌基礎研究 |
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| Research Abstract |
In order to clarify the direct cause of childhood thyroid cancers rapidly increased after the Chernobyl accident and its health consequences, we have successfully performed the joint research projects on molecular epidemiology on a basis of overseas' counterparts. Especially we could deeply commit to the international radiation safety programs with WHO, NCRP and EU and further deepened our understanding of radiation risk analysis and management with them. We have continued the collection of data on radiation-exposed victims and their biomaterials from the former USSR (Belarus, Ukraine and Russia), and extracted the DNAs which were subjected to further analysis of SNPs including the major target genes such as DNA damage repairing enzymes. Our results indicated the positive association of some SNPs pattern with radiation-associated thyroid cancers including DNA damage repairing enzymes and anti-oncogenes. Simultaneously we have worked at the Chernobyl Tissue Bank under the international
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consortium program. Using the samples collected from Chernobyl, we have analyzed the pathological changes of radiation-associated thyroid cancers and found the clinico-pathological characteristics such as genotype-phenotype difference by its different aged group, latency difference and histological difference. Fortunately there are no clinical prognostic difference between non-radiation and radiation-induced thyroid cancers at the standpoint of recurrence rate and mortality, suggesting a fairly good prognosis of childhood thyroid cancers after appropriate therapy. Now the genome wide association study is under investigation using the samples collected from Chernobyl.
In conclusion, we have contributed to the revision of radiation safety guidelines on a basis of active participation on WHO and other international meetings using our own achievement. Besides the risk of external radiation exposure, internal exposure by radioactive iodines to neonate and children selectively and specifically increased the risk of radiation-induced thyroid cancers. Therefore our research progress can be expected to contribute to fundamental data on preventive measures of nuclear disaster and radiation safety standard guidelines that are also socially of a great significance. Less
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Research Products
(65 results)
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[Journal Article] The usual ultrasonographic features of thyroid cancer are less frequent in small tumors that develop after a long latent period after the Chernobyl radiation release accident.2009
Author(s)
Drozd VM, Lushchik ML, Polyanskaya ON, Fridman MV, Demidchik YE, Lyshchik AP, Biko J, Reiners C, Shibata Y, Saenko VA, Yamashita S
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Journal Title
Thyroid 19(7)
Pages: 725-734
Peer Reviewed
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[Journal Article] Expanding indications for recombinant human TSH in thyroid cancer.2008
Author(s)
Haugen BR, Cooper DS, Emerson CH, Luster M, Maciel RM, Biscolla RP, Mazzaferri EL, Medeiros-Neto G, Reiners C, Robbins RJ, Robinson BG, Schlumberger M, Yamashita S, Pacini F
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Journal Title
Thyroid 18(7)
Pages: 687-694
Peer Reviewed
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[Journal Article] DHMEQ, a novel NF-{kappa}B inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.2008
Author(s)
Meng Z, Mitsutake N, Nakashima M, Starenki D, Matsuse M, Takakura S, Namba H, Saenko V, Umezawa K, Ohtsuru A, Yamashita S
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Journal Title
Endocrinology 149(11)
Pages: 5357-5365
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[Journal Article] Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer.2007
Author(s)
Kumagai A, Namba H, Akanov Z, Saenko VA, Meirmanov S, Ohtsuru A, Yano H, Maeda S, Anami M, Hayashi T, Ito M, Sagandikova S, Eleubaeva Z, Mussinov S, Espenbetova M, Yamashita S
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Journal Title
Endocr J 54(3)
Pages: 399-405
Peer Reviewed
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[Presentation] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbian patients.2009
Author(s)
B. Stanojevic, R. Dzodic, V. Saenko, Z. Milovanovic, G. Pupic, O. Jovanovic, L. Markovic, I. Djurisic, M. Buta, T. Rogounovitch, N. Akulevich, N. Mitsutake, S. Yamashita.
Organizer
9th Asia and Oceania Thyroid Association Congress.
Place of Presentation
Nagoya
Year and Date
20091101-20091104
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[Presentation] Clinical interview of mental health status of A-Bomb survivors in Korea.2009
Author(s)
Koshimoto R, Nakane H, Moon DS, Kinoshita H, Kim H, Bahn G, Nishihara K, Kumagai A, Ohtsuru A, Shibata Y, Ozawa H.
Organizer
International Conference of Asia Pacific Psychology (ICAPP).
Place of Presentation
Seoul, Korea
Year and Date
20090824-20090825
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