2009 Fiscal Year Final Research Report
Predicting Antigenic Changes of Influenza Viruses by Discovering Patterns of Viral Evolution
| Project/Area Number |
19300041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Intelligent informatics
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Kimihito Hokkaido University, 人獣共通感染症リサーチセンター, 准教授 (60396314)
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
MINATO Shin-ichi 北海道大学, 大学院・情報科学研究科, 准教授 (10374612)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 知識発見とデータマイニング |
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| Research Abstract |
Human influenza viruses mutate from time to time, causing annual epidemics worldwide. Given the high mutation rate of the viral gene, it is difficult to select an effective vaccine strain prior to each influenza season. In order to elucidate the pattern of viral evolution, we introduce a bioinformatics technology that analyzes a large number of epidemic strains in a multidimensional space. We found that the relative sequence distances among past epidemic strains could be predicted by a mathematical model. Retrospective tests for 12 years showed that the model could predict the direction of viral evolution with high accuracy.
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Research Products
(22 results)
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[Journal Article] Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin2010
Author(s)
Igarashi, M., Ito, K., Yoshida, R., Tomabechi, D., Kida, H., Takada, A.
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Journal Title
PLoS ONE 5(1)
Pages: e8553
Peer Reviewed
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[Journal Article] Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia.2009
Author(s)
Simulundu, E., Mweene, A.S., Tomabechi, D., Hang'ombe, B.M., Ishii, A., Suzuki, Y., Nakamura, I., Sawa, H., Sugimoto, C., Ito, K., Kida, H., Saiwana, L., Takada, A.
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Journal Title
Arch Virol 154(9)
Pages: 1517-1522
Peer Reviewed
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[Journal Article] Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses2009
Author(s)
Yoshida, R., Igarashi, M., Ozaki, H., Kishida, N., Tomabechi, D., Kida, H., Ito, K., Takada, A.
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Journal Title
PLoS Pathog 5(3)
Pages: e1000350
Peer Reviewed
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