2009 Fiscal Year Final Research Report
Mechanisms for the dendritic formation by ADP ribosylation factor 6 and its functional significance in higher brain functions
| Project/Area Number |
19300119
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kitasato University |
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Principal Investigator |
SAKAGAMI Hiroyuki Kitasato University, 医学部, 教授 (90261528)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経可塑性 / 樹状突起 / 棘突起 / 細胞骨格 / シナプス |
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| Research Abstract |
The aim of this study is to dissect the molecular mechanism by which ADP ribosylation factor 6 (ARF6) regulates dendritic formation. First, we found that IQ-ArfGEF/BRAG1 functions as a guanine nucleotide exchange factor for ARF6 at the postsynaptic density of excitatory synapses by interacting with the PSD-95 family and IRSp53. Second, we isolated vezatin as a novel ARF6-interacting protein by yeast two hybrid screening. Furthermore, we provided the strong evidence for the functional involvement of vezatin in the dendritic formation of cultured hippocampal neurons using the RNA interference approach. These findings suggest that vezatin regulates dendritic formation downstream of ARF6.
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[Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons2010
Author(s)
Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
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Journal Title
Peer Reviewed
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[Journal Article] Surgical management of severe scoliosis with high risk pulmonary dysfunction in Duchene muscular dystrophy: patient function, quality of life and satisfaction.2010
Author(s)
Takaso M, Nakazawa T, Imura T, Okada T, Fukushima K, Ueno M, Takahira N, Takahashi K, Yamazaki M, Ohtori S, Okamoto H, Okutomi T, Okamato M, Masaki T, Uchinuma E, Sakagami H
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Journal Title
International Orthopaedics (印刷中)
Peer Reviewed
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[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010
Author(s)
Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T.
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Journal Title
Peer Reviewed
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[Journal Article] COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems.2010
Author(s)
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, 他4名
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Journal Title
Am J Pathol 176
Pages: 1469-1483
Peer Reviewed
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[Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis.2010
Author(s)
Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, 他5名
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Journal Title
Biomed Pharmacother 64
Pages: 101-106
Peer Reviewed
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