2009 Fiscal Year Final Research Report
Computational analysis of human proteins addressing the relationship between intrinsic disorder and alternative splicing
| Project/Area Number |
19310133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
NISHIKAWA Ken Maebashi Institute of Technology, 工学部・生命情報学科, 教授 (10093288)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUCHI Satoshi 国立遺伝学研究所, 助教 (70360336)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 情報解析 / 天然変性タンパク質 / スプライシング / 真核生物 / ゲノム |
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| Research Abstract |
For all human proteins encoded on the genome, we have succeeded to classify protein molecules into structured or intrinsically disordered (ID) regions using the method we developed in this project. As a result, we revealed the total fractions of ordered/disordered regions of human proteins at a first time. Analyzing locations of alternative splicing (AS) data along the protein sequence, we have also revealed that AS events occur in proportion to the fraction of ID regions of proteins.
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[Journal Article] The GTOP database in 2009: updated content and novel features to expand and deepen insights into protein structures and functions.2009
Author(s)
Fukuchi, S., Homma, K., Sakamoto, S., Sugawara, H., Tateno, Y., Gojobori, T., Nishikawa, K.
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Journal Title
Nucl. Acids Res. 37
Pages: D333-D337
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