2009 Fiscal Year Final Research Report
Functional design of artificial mucin based Influenza virus Inhibitor in overcoming the mutation
| Project/Area Number |
19310141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Shizuoka University |
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Principal Investigator |
USUI Taiichi Shizuoka University, 農学部, 教授 (50111802)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Takeomi 静岡大学, 農学部, 准教授 (30273171)
PARK Enoch 静岡大学, 創造科学技術大学院, 教授 (90238246)
SUZUKI Takashi 静岡県立大学, 薬学部, 教授 (20240947)
HIDARI Kazuya 静岡県立大学, 薬学部, 准教授 (20260226)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 糖鎖工学 / 人工ムチン / インフルエンザウイルス / 複合糖質 / 分子認識 / 糖鎖ミメティックス |
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| Research Abstract |
インフルエンザウイルスの感染、接着に関わる特定の受容体シアロオリゴ糖鎖を高い効率且つ単純な手法で高密度に天然素材ポリペプチドである納豆菌由来γ-ポリグルタミン酸ベースに配して抗原性の変異を克服しかつトリ型およびヒト型インフルエンザウイルスに対応した強力な抗インフルエンザウイルス剤を構築した。また、感染阻害試験の結果から両型の受容体糖鎖特異性は末端シアル酸の結合様式において異なるだけでなく、そのコアとなる内部糖鎖構造も活性に大きく関与していることを実証した。
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Research Products
(28 results)
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[Journal Article] Molecular design of N-linked tetravalent glycosides bearing N-acetylglucosamine, N, N'-dicetylchitobiose and N-acetyllactosamine: Analysis of crosslinking activities with specific lectins.2010
Author(s)
Masaka, R., Ogata, M., Misawa, Y., Yano M., Hashimoto, C., Murata, T., Kawagishi, H., Usui, T
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Journal Title
Bioorg. Med. Chem 18
Pages: 621-629
Peer Reviewed
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[Journal Article] Chemoenzymatic synthesis of sialoglycopolypeptides as glycomimetics to block infection by avian and human influenza virus.2009
Author(s)
Ogata, M., Hidari, K., Murata, T., Shimada, S., Kozaki, W., Park, E.Y., Suzuki, T., Usui, T
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Journal Title
Bioconjugate Chem 20
Pages: 538-549
Peer Reviewed
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[Journal Article] Moelcular design of spacer N-linked sialoglycopolypeptide as polymeric inhibitors against influenza virus infection.2009
Author(s)
Ogata, M., Hidari, K., Kozaki, K., Murata, T., Hiratake, J., Park, E.Y., Suzuki, T., Usui, T
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Journal Title
Biomacromolecules 10
Pages: 1894-1903
Peer Reviewed
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[Journal Article] Synthesis of sialoglycopolypeptide for potentially blocking influenza virus using a ratα2, 6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae.2009
Author(s)
Ogata, M., Nakajima, M., Kato, T., Obara, T., Yagi, H., Kato, K., Usui, T., Park, E. Y
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Journal Title
BMC Biotechnol 9
Pages: 1-13
Peer Reviewed
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[Journal Article] Efficient synthesis of spacer-N-limked double-headed glycosides N-acetylglucosamine and N, N'-diacetylchitobiose their cross-linking activities with wheat germ agglutinin.2008
Author(s)
Misawa, Y., Masaka, R., Maeda, K., Yano, M., Murata, T., Kawagishi, H., Usui, T
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Journal Title
Carbohydr. Res 347
Pages: 434-442
Peer Reviewed
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[Journal Article] characterization and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection.2008
Author(s)
Hidari, K., Murata, T., Yoshida, K., Takahashi, Y., Minamijima, Y., Miwa, Y., Adachi, S., Ogata, M., Usui, T., Suzuki, Y., Suzuki, T. Chemoenzymatic synthesis
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Journal Title
Glycobiology 18
Pages: 779-788
Peer Reviewed
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[Journal Article] Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with aγ-polyglutamic acid backbone and their effect for inhibition of infection by influenza viruses. Bioorg.2007
Author(s)
Ogata, M., Murata, T., Murakami, K., Suzuki, T., Hidari, K., Suzuki, Y., Uusi, T
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Journal Title
Med. Chem 15
Pages: 1383-1393
Peer Reviewed
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