2009 Fiscal Year Final Research Report
Development of Laser desorption/ionization mass spectrometry using 2D ordered nanoparticles on substrates
| Project/Area Number |
19350045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
ARAKAWA Ryuichi Kansai University, 化学生命工学部, 教授 (00127177)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Hideya 関西大学, 化学生命工学部, 准教授 (50322285)
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| Project Period (FY) |
2007 – 2009
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| Keywords | レーザー脱離イオン化質量分析法 / ナノ粒子 / SALDI-MS / 環境分析 / バイオ分析 |
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| Research Abstract |
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices is a soft ionization technique that causes very less fragmentation of the analytes. However, matrix ion interface and detector saturation are inevitable in the MALDI-MS analysis of low-mass molecules (<m/z 500), and this makes the characterization of small molecules difficult despite the significance of such characterization. As an approache involving the use of organic-matrix-free LDI-MS for analyzing small molecules in a MALDI instrument, we have investigated a new and facile method for synthesizing two-dimensional (2D) nanoparticles on substrates for the applications of surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS). New types of nanostructured substrates for organic-matrix-free LDI-MS have been found : (1) Platinum nanoflowers, (2) rod-like zinc oxide nanoparticles,, (3) urea-modified titania nanoparticles, and (4) FePtCu magnetic nanoparticles. The feasibility of using these nanomaterials for SALDI-MS has been demonstrated.
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