2010 Fiscal Year Final Research Report
Roles of hyper-anisotropic dynamics and frustration on protein function investigated in sub-msec order
| Project/Area Number |
19370062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KITAO Akio The University of Tokyo, 分子細胞生物学研究所, 准教授 (30252422)
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| Project Period (FY) |
2007 – 2010
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| Keywords | タンパク質 / 超異方性 / 動態 / 機能 / フラストレーション |
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| Research Abstract |
To elucidate the detailed protein functional principle in broad time and space ranges, we focused on the dynamics of nano to sub-milli sec order, observed function relevant protein dynamics by molecular simulation, and studied the hyper anisotropy and frustration of the systems. We also have developed the methods to calculate free energy landscape from massive parallel simulations and to extract correlated motions in high dimensional dynamics and used them to investigate the relation between protein dynamics and function.
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