2009 Fiscal Year Final Research Report
Molecular mechanism that induces cytokinesis
| Project/Area Number |
19370080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Gakushuin University |
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Principal Investigator |
MABUCHI Issei Gakushuin University, 理学部, 教授 (40012520)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 遺伝子 / 細胞・組織 / シグナル伝達 / 生体分子 / 蛋白質 |
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| Research Abstract |
Actin was purified from fission yeast cells for the first time, and it was shown to polymerize into filaments that are indistinguishable from muscle actin filaments. The contractile ring actin filaments were visualized and their directionality was determined. Filaments were shown to shorten during contraction of the ring. We proposed that actin first polymerizes at one point in the division plane to both directions, and then the directionality was mixed in the ring prior to contraction. Using cultured fly cells we showed that myosin molecules in the cytoplasm accumulate at the division cortex during cytokinesis.
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[Book]2008
Author(s)
馬渕一誠
Total Pages
209
Publisher
ウニ卵の収縮環の蛍光像.細胞工学27
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