2009 Fiscal Year Final Research Report
Elucidation of the binding mode of DNA repair promoting protein to strand breaks
| Project/Area Number |
19380054
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
NARUMI Issay Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究主幹 (90343920)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKI Ryota 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主席 (30391246)
YURA Kei お茶の水女子大学, 大学院・人間文化創成科学研究科, 教授 (50252226)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 放射線 / 遺伝子 / 微生物 / タンパク質 / DNA修復 |
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| Research Abstract |
Crystal structure analysis of the Deinococcus radiodurans DNA repair promoting protein PprA was carried out at 1.35 A resolution, and the spatial configuration of amino acids important for DNA binding was elucidated. PprM protein that modulates pprA expression was identified. A novel plasmid vector was developed for Deinococcus.
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