2009 Fiscal Year Final Research Report
Regulation of life style-related diseases by phytochemicals
| Project/Area Number |
19380072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
YAGASAKI Kazumi Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (20166474)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Yutaka 東京農工大学, 大学院・共生科学技術研究院, 准教授 (10219595)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食品機能学 / 生活習慣病 / 糖尿病 / ポリフェノール |
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| Research Abstract |
Type 2 diabetes, one of life style-related diseases and a member of metabolic syndrome, is increasing worldwide. Its main symptom is high blood glucose value. By constructing in vitro assay systems using cultured muscle cells and pancreatic β-cells, we have screened food components that have potentiality to stimulate glucose consumption and/or insulin secretion. Some food components such as soy isoflavones and grape stilbenoids were found to suppress increases in blood glucose levels and to improve impaired glucose tolerance in type 2 diabetic model mice. Modes of actions of these food components were clarified mainly at cellular levels.
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