2008 Fiscal Year Final Research Report
Study on mechanism of tissue degradation by membrane-type matrix metalloproteinase
| Project/Area Number |
19390084
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SATO Hiroshi Kanazawa University, がん研究所, 教授 (00115239)
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| Co-Investigator(Kenkyū-buntansha) |
TAKINO Takahisa 金沢大学, がん研究所, 准教授 (40322119)
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| Project Period (FY) |
2007 – 2008
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| Keywords | MT1-MMP / 組織破壊 / MMP-2 / GDF-15 / 細胞接着斑 / ERK / 細胞運動 / 分子標的 |
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| Research Abstract |
膜型マトリックスメタロプロテアーゼー1(MT1-MMP)の機能は、潜在型MMP-2の活性化と基質切断の2つに大別できる。人工的MMP-2受容体MSP-TIMP-2を考案してMMP-2活性化機構の解明とMMP-2活性化の生理的意義を明らかにした。また、MT1-MMP新規基質を同定し、がん浸潤・転移に果たす役割を解明した。さらにMT1-MMPの細胞接着斑における機能を解析し、細胞運動なに果たす役割を解明した。
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[Journal Article] Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha2009
Author(s)
Itatsu K, Sasaki M, Yamaguchi J, Ohira S, Ishikawa A, Ikeda H, Sato Y, Harada K, Zen Y, Sato H, Ohta T, Nagino M, Nimura Y, Nakanuma Y.
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Journal Title
Am. J. Pathol 174
Pages: 829-841
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[Journal Article] Phosphorylation of extracellular signal-regulated kinase 1/2, p^<38> mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha2008
Author(s)
Itatsu K, Sasaki M, Harada K, Yamaguchi J, Ikeda H, Sato Y, Ohta T, Sato H, Nagino M, Nimura Y, Nakanuma Y.
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Journal Title
Liver Int. 29
Pages: 291-298
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[Journal Article] Crosstalk between neovessels and mural cells directs the site- specific expression of MT1-MMP to endothelial tip cells2007
Author(s)
Yana, I., Sagara H., Takaki S., Takatsu K., Nakamura K., Nakao K., Katsuki M., Taniguchi S., Aoki T., Sato H., Weiss S.J., Seiki M.
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Journal Title
J. Cell Sci. 120
Pages: 1607-1614
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