2009 Fiscal Year Final Research Report
Study on host factors associated with retroviruses-induced diseases
| Project/Area Number |
19390131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NISHIGAKI Kazuo Yamaguchi University, 農学部, 准教授 (20401333)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 病原性 / 発癌 / レトロウイルス / 白血病 / 抵抗性因子 |
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| Research Abstract |
The critical amino acid sequences of sf-Stk in which Friend virus gp55 transforms NIH3T3 cells in cooperation with sf-Stk were identified. Several signal molecules were constitutively activated in the transformed cells. PI3-kinase, one of these molecules, was identified to interact with sf-Stk. Splenomegaly induced by Friend virus was depend on Fv-2 and p85 expression status. Futthermore, p85 was shown to involved in stress- induced erythropoiesis. HTLV-1 expression was associated with IL-2 withdrawal in cells and its regulation was due to via p38 stress pathway. Apoptosis-related molecules were elevated in cats with MDS induced by FeLV. These studies identified molecular mechanisms in retroviruses-induced diseases.
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Research Products
(11 results)
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[Presentation]2007
Author(s)
鷲山美幸, 西垣一男, 等
Organizer
第55回日本ウイルス学会学術集会.
Year and Date
20071021-20071023
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