2009 Fiscal Year Final Research Report
Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment
| Project/Area Number |
19390161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko Mie University, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食餌性因子 / 肥満 / 発がん / DNA損傷 / 細胞増殖作用 / 遺伝子発現 |
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| Research Abstract |
Estimates suggest that 35% of all human cancers have a linkage to dietary and obesity. Several reports showed the evidences of an association between obesity and cancer derives from cohort studies. To clarify the roles of obesity and dietary factors on multistage carcinogenesis and risk assessment, we examined DNA damage and ability for cell proliferation for chlorogenic acid, 2-nitrotoluene, phthalate and status of high glucose and oxidative stress. These factors could cause DNA damage and gene expression under several conditions, and therefore further studies are needed to prevent cancers due to dietary factors and obesity.
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[Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and the effect of anti-parasitic drug in relation to cholangiocarcinogenesis.2008
Author(s)
Thanan R., Murata M, Pinlaor S, Sithithaworn P, Khuntikeo N, Tangkanakul W, Hiraku Y, Oikawa S, Yongvanit P, Kawanishi S
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Journal Title
Cancer Epidemiol Biomarkers Prev 17(3)
Pages: 518-24
Peer Reviewed
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