2009 Fiscal Year Final Research Report
Investigation on regulation of the human blood group ABO gene transcription with a novel antisense RNA transcribed from the opposite strand
| Project/Area Number |
19390183
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
KOMINATO Yoshihiko Gunma University, 大学院・医学系研究科, 教授 (30205512)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Tamiko 群馬大学, 大学院・医学系研究科, 助教 (40008561)
SANO Rie 群馬大学, 大学院・医学系研究科, 助教 (70455955)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 血液型 |
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| Research Abstract |
We found a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene, and showed that the ABO and ABOAS transcripts appeared to exhibit reciprocal expression patterns in the cells expressing the ABO gene. These results suggest that ABOAS transcribed from the opposite strand of the ABO gene might be involved in the regulation of ABO gene expression.
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[Journal Article] Development of a Sensitive Enzyme-Linked Immunosorbent Assay for Measurement of DNase I in Human Serum2009
Author(s)
Nakajima T, Takagi-R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
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Journal Title
Clinica Chimica Acta 403
Pages: 219-222
Peer Reviewed
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[Journal Article] Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling2009
Author(s)
Kuribara J, Tada H, Kawai Y, Kawaguchi R, Hoshizaki H, Arakawa K, Kitayama M, Kajinami K, Kurabayashi M, Oshima S, Taniguchi K, Kominato Y, Yasuda T.
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Journal Title
Journal of Cardiology 53
Pages: 196-203
Peer Reviewed
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[Journal Article] Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme2009
Author(s)
Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, Panduro A, Nakajima-T, Kominato-Y, Yasuda T.
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Journal Title
Clinica Chimica Acta 407
Pages: 20-24
Peer Reviewed
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[Journal Article] α1, 2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Colorectal Cancer Compared with Blood Group A, B, or Sialyl Lewis X Antigen Generated within Colorectal Tumor Tissues2007
Author(s)
Tsuboi K, Asao T, Ide M, Hashimoto S, Noguchi K, Kominato Y, Kuwano H, Yazawa S.
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Journal Title
Annals of Surgical Oncology 146(6)
Pages: 1880-1889
Peer Reviewed
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[Journal Article] Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia : results in vasospastic angina pectoris induced by provocation test2007
Author(s)
Morikawa N, Kawai Y, Arakawa K, Kumamoto T, Miyamori I, Akao H, Kitayama M, Kajinami K, Lee J-D, Takeshita H, Kominato Y, Yasuda T.
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Journal Title
Eur.Heart J 28(24)
Pages: 2992-2997
Peer Reviewed
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[Presentation] 低酸素による核酸分解酵素DNase I遺伝子の転写調節2009
Author(s)
佐野利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
Organizer
日本DNA多型学会第18回学術集会
Place of Presentation
久留米
Year and Date
2009-11-19
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[Presentation] 核酸分解酵素DNase I遺伝子の転 写調節機構の解明2008
Author(s)
高木利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
Organizer
日本DNA多型学会第17回学術集会
Place of Presentation
東京
Year and Date
2008-11-26
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