Targeted radionuclide therapy for malignant neuroendcrine tumors combined with antiangiogenic therapy : from bench to bedside

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390317
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KINUYA Seigo Kanazawa University, 医学系, 教授 (20281024)
• Co-Investigator(Renkei-kenkyūsha): KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663) ; YOSHIMOTO Mitsuyoshi 国立がん研究センター, 研究員 (00345638) ; WASHIYAMA Koshin 金沢大学, 保健学系, 助教 (80313675) ; OGAWA Kazuma 金沢大学, 薬学系, 准教授 (30347471)
• Project Period (FY): 2007 – 2009
• Keywords: 放射線治療学 / 放射性医薬品 / 内用療法 / 神経内分泌腫瘍 / 血管新生阻害

Research Abstract

This study aimed to enhance therapeutic efficacy of targeted radionuclide therapy with ^<131>I-MIRG for malignant refractory neuroendcrine tumors. Locoregi onal administration of ^<131>I-MTRG was found to better prolong survival of mice with disseminated tumors than systemic administration. Feasibility of high-dose therapy based on dosimetric analysis was determined firstly in Japan. Fusion images of single photon emission computed tomography (SPFCT) and x-ray CT enabled precise detection of lesions and provided information for accurate dosimetry.

Research Products

• [Journal Article] Comparison of diagnostic value of 1-123 MIBG and high-dose 1-131 MIBG scintigraphy including incremental value of SPECT/CT over planar image in patients with malignant pheochromocytoma/paraganglioma and neuroblastoma. (2010)
  • Author(s): Fukuoka, M., Taki, J., Mochizuki, T., Kinuya S.
  • Journal Title: Clinical Nuclear Medicine 36 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 悪性褐色細胞腫に対する^<131>I-MIBG内照射療法 (2009)
  • Author(s): 絹谷清剛、米山達也、萱野大樹、若林大志、稲木杏里、中村文音、松尾信郎
  • Journal Title: 内分泌外科 25 Pages: 183-190
• [Journal Article] 131I-MIBGによる悪性褐色細胞腫の内照射療法 (2009)
  • Author(s): 絹谷清剛、米山達也、萱野大樹、若林大志、稲木杏吏、中村文音、松尾信郎
  • Journal Title: Current Therapy 27 Pages: 63-68
• [Journal Article] 内照射療法の最近の話題:メタストロン・ゼヴァリン・甲状腺癌 (2009)
  • Author(s): 絹谷清剛
  • Journal Title: 日本放射線技術学会雑誌 65 Pages: 659-667
• [Journal Article] Pereparation and evaluation of ^<186/848>Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site (2009)
  • Author(s): Ogawa, K.Kawashima, H., Kinuya S., Shiba, K., Onoguchi, M., Kimura, H., Hashimoto, K., Odani, A., Saji, H.
  • Journal Title: Annals of Nuclear Medicine 23 Pages: 843-848
  • Peer Reviewed
• [Journal Article] Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy (2009)
  • Author(s): Ogawa, K., Shiba, K., Akhter, N., Yoshimoto, M., Washiyama, K., Kinuya S., Kawai, K., Mori, H.
  • Journal Title: Cancer Science 100 Pages: 2188-2192
  • Peer Reviewed
• [Journal Article] Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice (2009)
  • Author(s): Yagi, Y., Fushida, S., Harada, S., Tsukada, T., Kinoshita, J., Oyama, K., Fujita, H., Ninomiya, T., Fujimura, T., Kayahara, M., Kinuya S., Yashiro, M., Hirakawa, K., Ohta, T.
  • Journal Title: Cancer Chemotherapy and Pharmacology 66 Pages: 745-753
  • Peer Reviewed
• [Journal Article] Localization of metastases from malignant pheochromocytoma in patients undergoing ^<131>I-MTBG therapy with manually fused ^<123>I-MIBG SPECT and CT images (2008)
  • Author(s): Kizu, H., Takayama, T., Tsushima, H., Noguchi, A., Nakajima, K., Onoguchi, M., Kinuya S.
  • Journal Title: Journal of Nuclear Medicine Technology 36 Pages: 186-188
  • Peer Reviewed
• [Journal Article] 悪性褐色細胞腫に対する^<131>I-MIBG内照射療法 (2008)
  • Author(s): 絹谷清剛、米山達也、萱野大樹、松尾信郎、若林大志、稲木杏里、中村文音
  • Journal Title: UrolDgy Review 6 Pages: 96-100
• [Presentation] 再発または進行性神経芽腫に対する^<131>I-MIBG内照射療法の中間報告 (2009)
  • Author(s): 若林大志、萱野大樹、福岡誠、稲木杏吏、中村文音、絹谷清剛
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2009-10-05
• [Presentation] 神経芽腫に対する大容量I-131MIBG治療の試み (2008)
  • Author(s): 萱野大樹、稲木杏吏、絹谷清剛
  • Organizer: 第44回腫瘍・免疫核医学研究会
  • Place of Presentation: ソニックシティ(埼玉県)
  • Year and Date: 2008-05-15
• [Presentation] 甲状腺癌内照射療法におけるSPECT/CTの初期経験 (2008)
  • Author(s): 中村文音、萱野大樹、若林大志、稲木杏里、米山達也、松尾信郎、絹谷清剛
  • Organizer: 第44回腫瘍・免疫核医学研究会
  • Place of Presentation: ソニックシティ(埼玉県)
  • Year and Date: 2008-05-15
• [Presentation] High dose MIBG治療を施行した悪性褐色細胞腫の一例 (2007)
  • Author(s): 萱野大樹、若林大志、米山達也、絹谷清剛
  • Organizer: 第43回腫瘍・免疫核医学研究会
  • Place of Presentation: タワーホール船堀(東京都
  • Year and Date: 2007-05-11
• [Book] 褐色細胞腫診療マニュアル(成瀬光栄、平田結喜緒編) (2008)
  • Author(s): 絹谷清剛、中條政敬、織内昇、吉永恵一郎、山口敏朗
  • Total Pages: 80-87
  • Publisher: 診断と治療社
• [Book] Nova Publishers, NewResearch on Angiogenesis (2007)
  • Author(s): 絹谷清剛
  • Total Pages: 77-98
  • Publisher: Inhibitors