2009 Fiscal Year Final Research Report
Multifunctional nanoparticles and its application for breast cancer surgery
| Project/Area Number |
19390329
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIDA Takanori Tohoku University, 大学院・医学系研究科, 准教授 (00292318)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808)
OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 乳がん / 多機能ナノ粒子 / 蛍光ナノビーズ / センチネルリンパ節 / 複合ナノ粒子 |
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| Research Abstract |
Nanoparticles in appropriate size can be passively transported in malignant tissue. We performed in vivo imaging of the dynamics of nanoparticles in various sizes. Nanoparticles of 200nm did not leak in cancer tissue. In contrast, nanoparticles of 20, 40 and 100nm could be transported in cancer tissue. We also performed fluorescence nanoimaging of gastric sentinel lymph node of pigs. And we specified the first area for lymph node metastasis in a sentinel lymph node. These techniques are also utilized for ultrafine cancer operation.
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Research Products
(23 results)
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[Journal Article] Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2 overexpressing metastatic breast cancers resistant to both anthracyclines and taxanes2009
Author(s)
Ishida T, Kiba T, Takeda M, Matsuyama K, Teramukai S, Ishiwata R, Masuda N, Yuichi Takatsuka Y, Noguchi S, Ishioka C, Fukushima M, Ohuchi N
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Journal Title
Cancer Chemother Pharmacol 64
Pages: 361-369
Peer Reviewed
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[Presentation] Nanosized Silver-Iodide Beads as Novel X-ray Contrast Media for Cancer Detection Breast Cancer, 15, Supplement 1, 37-37, 20082008
Author(s)
Takeda M, Sakurai Y, Kobayashi Y, Cong L, Hikage M, Amari M, Ishida T, Gonda K, Ohuchi N.
Organizer
The 26^<th> Congress of the International Association for Breast Cancer Research
Place of Presentation
Kurashiki, Japan
Year and Date
20080922-20080924
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[Presentation] In Vivo Imaging of Vascular Permeability Using Nano-Objects in Mice Tumor. Breast Cancer, 15, Supplement 1, 33-33, 20082008
Author(s)
Kawai M, Takeda M, Ishida T, Suzuki A, amari M, Ohuchi N.
Organizer
The 26^<th> Congress of the International Association for Breast Cancer Research
Place of Presentation
Kurashiki, Japan
Year and Date
20080922-20080924
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[Presentation] Phase II study of Capecitabine and Trastuzumab combination chemotherapy in patients with HER2 overexpressing metastatic breast cancers after failure of both Anthracyclines and Taxanes2008
Author(s)
Ishida T, Kiba, T, Takeda M, Matsuyama K, Teramukai S, Masuda N, Takatsuka Y, Noguchi S, Fukushima M, Ohuchi N
Organizer
The 44th American Society of Clinical Oncology (ASCO) Annual Meeting
Place of Presentation
Chicago
Year and Date
20080530-20080603
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