2010 Fiscal Year Final Research Report
Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China
| Project/Area Number |
19406007
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
HASUI Kazuhisa Kagoshima University, 医歯学総合研究科, 講師 (70198703)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IZUMO Syuji 鹿児島大学, 医歯学総合研究科, 教授 (30143811)
KANEKURA Takuro 鹿児島大学, 医歯学総合研究科, 教授 (70177509)
MATSUYAMA Takami 鹿児島大学, 医歯学総合研究科, 教授 (30145479)
EIZURU Yoshito 鹿児島大学, 医歯学総合研究科, 教授 (00041351)
KAWANO Yoshifumi 鹿児島大学, 医歯学総合研究科, 教授 (20260680)
YONEZAWA Sugury 鹿児島大学, 医歯学総合研究科, 教授 (10175002)
KANZAKI Tamotu 鹿児島大学, 医歯学総合研究科, 教授 (80118801)
|
|---|
| Research Collaborator |
JIA Xinshan 中国医科大学, 病理研教室, 教授
WANG Jia 鹿児島大学, 医歯学総合研究科, 院生
TAKEYA Motohiro 熊本大学, 医学薬学研究部, 教授 (90155052)
AKAIKE Takaaki 熊本大学, 医学薬学研究部, 教授 (20231798)
SATO Eiichi 鹿児島大学, 名誉教授
OKUMURA Teruhisa 鹿児島生協病院, 病理部, 部長
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 鼻型NK / T細胞リンパ腫 / 鼻咽頭癌 / 中国東北地方 / (免疫)組織化学 / 腫瘍共生樹状細胞 / Epstein-Barr virus (EBV) / プログラム細胞死 / 酸化ストレス |
|---|
| Research Abstract |
This study examined many cases of nasopharyngeal lymphomas frequently seen in northeast China, elucidating neoplastic expansion of Epstein-Barr virus (EBV) latent infection, complication of minute EBV-not-associated squamous cell carcinoma in EBV-associated NK/T-cell lymphomas, peculiar necrosis of autophagic cell death, lymphoma cells' antioxidant response suggesting point mutations induced by environmental factors before its occurrence, and peculiar symbiotic dendritic cells and developed immunohistochemical methods of malignant tumor diagnosis by detecting a nature of tissue stem cells, analysis for autophagy and its cell death, and analysis for oxidation in DNA.
|
