Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy

2009 Fiscal Year Final Research Report

• Project/Area Number: 19406028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: OHNO Shigeaki Hokkaido University, 大学院・医学研究科, 特任教授 (50002382)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Susumu 北海道大学, 大学院・医学研究科, 教授 (10245558) ; YOSHIDA Kazuhiko 北海道大学, 大学病院, 講師 (90281807) ; NAMBA Kenichi 北海道大学, 大学病院, 助教 (70333599) ; KITAICHI Nobuyoshi 北海道大学, 大学病院, 助教 (40431366) ; TAGAWA Yoshitsugu 北海道大学, 大学院・医学研究科, 准教授 (40109426) ; ONOE Kazunori 北海道大学, 遺伝子病制御研究所, 教授 (40002117)
• Co-Investigator(Renkei-kenkyūsha): MIZUKI Nobuhisa 横浜市立大学, 医学部, 教授 (90336579) ; INOKO Hidetoshi 東海大学, 医学部, 教授 (10101932)
• Project Period (FY): 2007 – 2009
• Keywords: 疾患感受性遺伝子 / ベーチェット病 / 難治性内眼炎 / アデノウイルス角結膜炎 / 分子疫学

Research Abstract

In GWAS studies in Behcet disease, 2 new genes and HLA-B*510101 were found. In Vogt-Koyanagi-Harada disease, HLA-DRB1*0405 and several genetic associations were also found. Virological studies revealed 2 new human adenoviruses (HAdV 53 and 54). One of the carotenoids, astaxanthin showed significant increase of choroidal blood flow. DHMEQ, a new NF-κB blocker also showed significant suppression of experimental uveoretinitis.

Research Products

• [Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan (2009)
  • Author(s): Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N
  • Journal Title: Mol Vis VOL. 15 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients (2009)
  • Author(s): Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Asukata Y, Inoko H, Mizuki N, Ishida S, Ohno S
  • Journal Title: Mol Vis VOL. 15 Pages: 1115-1119
  • Peer Reviewed
• [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population (2009)
  • Author(s): Horie Y, Neguro A Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song Y W, ParkK S, Lee E B, Inoko H, Mizuki N, Ohno S
  • Journal Title: Rheumatology VOL. 48 Pages: 638-642
  • Peer Reviewed
• [Journal Article] Investigation of the association between the GLC3A locus andnormal tension glaucoma in Japanese patients by microsatellite analysis (2009)
  • Author(s): Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S,Inoko H, Mizuki N
  • Journal Title: Clin Ophthalmol VOL. 3 Pages: 183-188
  • Peer Reviewed
• [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis (2009)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci VOL. 50 Pages: 5909-5912
  • Peer Reviewed
• [Journal Article] Low prevalence of juvenile-onset Behcet's diease with uveitis in east/south Asian people (2009)
  • Author(s): Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S
  • Journal Title: Br J Ophthalmol VOL. 93 Pages: 1428-1430
  • Peer Reviewed
• [Journal Article] Clinical features of intraocular inflammation in Hokkaido, Japan (2009)
  • Author(s): Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A, Ohno S
  • Journal Title: Acta Ophthalmol VOL. 87 Pages: 424-428
  • Peer Reviewed
• [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population (2009)
  • Author(s): Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M,Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N
  • Journal Title: Clin Ophthalmol VOL. 3 Pages: 307-312
  • Peer Reviewed
• [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3 (2009)
  • Author(s): Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N
  • Journal Title: Eye VOL. 23 Pages: 222-229
  • Peer Reviewed
• [Journal Article] Investigation of the association between toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients (2009)
  • Author(s): Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N
  • Journal Title: VOL. 70 Pages: 41-44
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats (2008)
  • Author(s): Miyazaki A, Kitaichi N, OhgamiK, Iwata D, Jin XH, Iwabuchi K, Morohashi T, Ohno S, Onoe K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol VOL. 246 Pages: 747-757
  • Peer Reviewed
• [Journal Article] Guidelines for the diagnosis of ocular sarcoidosis (2008)
  • Author(s): Asukata Y, Ishihara M, Hasumi Y, Nakamura S, Hayashi K, Ohno S, Mizuki N
  • Journal Title: Ocul Immunol Inflamm VOL. 16 Pages: 77-81
  • Peer Reviewed
• [Journal Article] Sister cases of Behcet's disease and Vogt-Koyanagi-Harada disease (2008)
  • Author(s): Horie Y, Namba K, Kitaichi N, Ohno S
  • Journal Title: Br J Ophthalmol VOL. 92 Pages: 433-434
  • Peer Reviewed
• [Journal Article] Evaluation of mixed infection cases with both herpes simplex virus types 1 and 2 (2008)
  • Author(s): Kaneko H, Kawana T, Ishioka K, Ohno S, Aoki K, Suzutani T
  • Journal Title: J Med Virology VOL. 80 Pages: 883-887
  • Peer Reviewed
• [Journal Article] Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease (2008)
  • Author(s): Horie Y, Kitaichi N, Takemoto Y, Namba K, Yoshida K, Hirose S, Hasumi Y, Ota M, Inoko H, Mizuki N, Ohno S
  • Journal Title: Mol Vis VOL. 92 Pages: 2334-2338
  • Peer Reviewed
• [Journal Article] Primary central nervous system lymphoma with intraocular recurrence after optic nerve disorder (2007)
  • Author(s): Horie Y, Saito W, Kase S, Yoshida K, Ohno S
  • Journal Title: Retinal Cases & Brief Reports VOL. 1 Pages: 165-168
  • Peer Reviewed
• [Journal Article] Lack of Association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients (2007)
  • Author(s): Ito A, Ota M, Katsuyama Y, Inoko H, Ohno S, Mizuki N
  • Journal Title: Tissue Antigens VOL. 70 Pages: 423-426
  • Peer Reviewed
• [Presentation] Ocular Inflammatory Disease : Clinical pictures of sarcoidosis (2009)
  • Author(s): Ohno S.
  • Organizer: The 12th Seoul National University-Hokkaido University Joint Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-11-19
• [Presentation] Clinical features of intraocular inflammation in Asia-Pacific region (2009)
  • Author(s): Ohno S, Namba K, Kitaichi N, Ishida S.
  • Organizer: The 4th Congress of the Asia-Pacific Vitreo-Retinal Society
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-11-12
• [Presentation] Intraocular inflammation in Asia (2009)
  • Author(s): Ohno S, Kitaichi N, Namba K.
  • Organizer: The 2nd International Uveitis/The 3rd Asia Pacific Intraocular Inflammation/The 8th Chinese Ocular Immunology Combined Symposium
  • Place of Presentation: Chongqing, China
  • Year and Date: 2009-11-06
• [Presentation] Young Investigator Award Lecture : Low prevalence of juvenile-onset Behcet's disease with uveitis in east/south Asian people (2009)
  • Author(s): Kitaichi N, Ohno S.
  • Organizer: The 2nd International Uveitis Symposium/The 3rd Asia-Pacific Intraocular Inflammation Symposium/The 8th Chinese Ocular Immunology Symposium
  • Place of Presentation: Chongqing, China
  • Year and Date: 2009-11-06
• [Presentation] Clinical features of Behcet's disease (2009)
  • Author(s): Ohno S, Lennikov A
  • Organizer: Meeting in Research Institution of Rheumatology Diseases
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2009-09-15
• [Presentation] Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Ohno S.
  • Organizer: SOE 2009 : The 17th Congress of the European Society of Ophthalmology
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2009-06-13
• [Presentation] Early systemic corticosteroid therapy may reduce ocular complications in Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Ohno S, Hirose S, Kitaichi N.
  • Organizer: The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2009-02-28
• [Presentation] Diagnosis of Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Ohno S, Kitaichi N.
  • Organizer: The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2009-02-27