2010 Fiscal Year Final Research Report
Self-organization mechanisms of topology of local neural circuit
| Project/Area Number |
19500256
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioinformatics/Life informatics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KARASHIMA Akihiro 東北大学, 大学院・情報科学研究科, 助教 (40374988)
NAKAO Mitsuyuki 東北大学, 大学院・情報科学研究科, 教授 (20172265)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 脳情報処理 |
|---|
| Research Abstract |
In this study, we investigated the dynamics and self-organization of cortical local neural network by electrophysiological experiments on acute brain slices, mathematical modeling and computer simulations of realistic neural network. It was found that autonomous change of functional neural connections occurred associated with metastable dynamics of ensemble neuronal activities in the local neural circuit. In addition, it is suggested that a certain degree of robustness of the distribution of efficacy of functional neuronal connections against the self-organization of the network.
|
