2009 Fiscal Year Final Research Report
Neuronal mechanisms for determination of basic respiratory cycle by dual rhythm generators in the medulla
| Project/Area Number |
19500277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Showa University |
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Principal Investigator |
ONIMARU Hiroshi Showa University, 医学部・第二生理, 准教授 (30177258)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 呼吸リズム / 傍顔面呼吸ニューロン / 延髄 |
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| Research Abstract |
Two distinct neuronal networks ; the pre-Botzinger complex (pre-BotC) and the parafacial respiratory group (pFRG), in the ventrolateral medulla (VLM) are involved in respiratory rhythm generation. In the present study, we have studied the neuronal mechanisms for determination of basic respiratory rhythm by interaction between these neuron groups. We found that the pFRG is necessary for postnatal survival because of its involvement in rhythm generation and central chemoreception in the neonatal system.
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[Journal Article] Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column.2007
Author(s)
Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Kamayachi T, Hayashi K, Saruta T, Itoh H.
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Journal Title
Am J Physiol Regul Integr Comp Physiol. 292
Pages: R927-36
Peer Reviewed
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