2009 Fiscal Year Final Research Report
Study of a novel K^+ channel in generation of neuropathic pain
| Project/Area Number |
19500353
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | Hyogo University of Health Sciences |
|---|
Principal Investigator |
YAMAMOTO Satoshi Hyogo University of Health Sciences, 薬学部, 教授 (60220464)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIZAKI Tomoyuki 兵庫医科大学, 医学部, 教授 (00221474)
NAGATA Tetsu 兵庫医科大学, 医学部, 准教授 (60131588)
YAMAMOTO Hideyuki 兵庫医科大学, 医学部, 講師 (70373529)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 感覚系神経生理学 / 神経因性疼痛 / イオンチャネル / 熱 / 脊髄後根神経節 |
|---|
| Research Abstract |
The results of the present study show that heat-activated K^+ channel currents in DRG neurons are inhibited by both PKC and PKA as mediated via alpha1 and beta adrenergic receptors, respectively. This may represent a new insight into regulation of thermosensation via a noradrenergic pathway, leading to revealing the mechanisms of neurogenic pain.
|
Research Products
(3 results)
