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2008 Fiscal Year Final Research Report

Glucose transport mechanism in the cochlea stria vascularis

Research Project

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Project/Area Number 19570058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphology/Structure
Research InstitutionOkayama University

Principal Investigator

ANDO Motonori  Okayama University, 大学院・教育学研究科, 准教授 (20222789)

Project Period (FY) 2007 – 2008
Keywords組織構築 / 辺縁細胞 / 基底細胞 / グルコーストランスポーター / RT-PCR / 共焦点レーザー顕微鏡
Research Abstract

内耳血管条機能の根幹を支える糖輸送機構を明らかにする目的で, それに関わる糖輸送分子の組織特異的な遺伝子発現およびタンパク質発現を明らかにした。その結果, 糖輸送体分子の一つであるGLUT-1型が血管条構成細胞の中で基底細胞と血管構成細胞に発現していることや, 新たに複数のGLUT型の輸送体の遺伝子発現を確認した。血管条では複数の促進拡散型糖輸送体が連携してその高いエネルギー代謝活性をを支えているものと考えられた。

  • Research Products

    (6 results)

All 2009 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect2009

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T.
    • Journal Title

      J Thorac Cardiovasc Surg 137

      Pages: 223-231

    • Peer Reviewed
  • [Journal Article] Cellular localization of facilitated glucose transporter 1(GLUT-1)in the cochlea stria vascularis : its possible contribution to the transcellular glucose pathway2008

    • Author(s)
      Ando M, Edamatsu M, Fukuizumi S, Takeuchi S.
    • Journal Title

      Cell Tissue Res 331

      Pages: 763-769

    • Peer Reviewed
  • [Journal Article] Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin2007

    • Author(s)
      Kuwabara M, Kakinuma Y, Katare RG, Ando M, Yamasaki F, Doi Y, Sato T.
    • Journal Title

      FEBS Lett 581

      Pages: 4821-4830

    • Peer Reviewed
  • [Presentation] Cell-specific expression of glucose transporter in the cochlear stria vascularis2008

    • Author(s)
      Edamatsu M, Enomoto T, Fukuizumi S, Ando M.
    • Organizer
      第79回日本動物学会大会
    • Place of Presentation
      @Fukuoka
    • Year and Date
      2008-09-05
  • [Presentation] Glucose transport mechanism in the cochlear stria vascularis2007

    • Author(s)
      Edamatsu M, Fukuizumi S, Ando M.
    • Organizer
      第78回日本動物学会大会
    • Place of Presentation
      @Hirosaki
    • Year and Date
      2007-09-20
  • [Remarks]

    • URL

      http://ed-www.ed.okayama-u.ac.jp/~rika/cell_physiology/index.html

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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