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2009 Fiscal Year Final Research Report

Structures and Functions of the N-terminal Domains of SUMO Ligase PIAS/Siz Family

Research Project

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Project/Area Number 19570115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionNational Institute of Agrobiological Sciences

Principal Investigator

YAMAZAKI Toshimasa  National Institute of Agrobiological Sciences, タンパク質機能研究ユニット, ユニット長 (40360458)

Co-Investigator(Renkei-kenkyūsha) SHINDO Heisaburo  独立行政法人農業生物資源研究所, タンパク質機能研究ユニット, 外来研究員 (80138966)
Project Period (FY) 2007 – 2009
Keywords生物物理 / 蛋白質 / 分子認識 / SUMO化翻訳後修飾 / SUMOリガーゼ / DNA結合 / ヒストン認識
Research Abstract

Post-translational modification of target proteins by SUMO regulates a wide variety of cellular functions. Among three enzymes (E1, E2 and E3) involved in the SUMO pathway, SUMO E3 ligases are thought to play important roles to recognize target proteins and facilitate their sumoylation. Here, we studied structures and functions of the N-terminal SAP and PHD of SUMO ligase PIAS/Siz family by NMR spectroscopy.

Research Products

(5 results)

All 2009 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Solution structures and DNA binding properties of the N-terminal SAP domains of SUMO E3 ligases from Saccharomyces cervisiae and Oryza sativa.2009

    • Author(s)
      Suzuki R, Shindo H, Tase A, Kikuchi Y, Shimizu M, Yamazaki T
    • Journal Title

      PROTEINS 75(2)

      Pages: 336-347

    • Peer Reviewed
  • [Presentation] SUMOリガーゼSiz/PIASファミリーの構造と機能に関する研究2009

    • Author(s)
      山崎俊正
    • Organizer
      第7回SUMO研究会
    • Place of Presentation
      兵庫県三田市
    • Year and Date
      2009-11-22
  • [Presentation] Structure and function of the N-terminal domains of SUMO ligase Siz/PIAS family2007

    • Author(s)
      Yamazaki T, Suzuki R, Tase A, Nishiuchi Y, Shindo H
    • Organizer
      The 4th International Peptide Symposium
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2007-10-24
  • [Presentation] NMR structures and self-sumoylation of the N-terminal SAP domains of SUMO PIAS/Siz family2007

    • Author(s)
      Suzuki R, Shindo H, Tase A, Yamazaki T
    • Organizer
      第47回NMR討論会
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-13
  • [Presentation] N-terminal SAP and PHD-finger domains of SUMO ligase Siz1 from Oryza sativa are essential for recognition of methylated histone as well as DNA binding2007

    • Author(s)
      Yamazaki T, Suzuki R, Tase A, Nishiuchi Y, Shindo H
    • Organizer
      第47回NMR討論会
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-12

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Published: 2011-06-17   Modified: 2016-04-21  

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