2009 Fiscal Year Final Research Report
Regulation mechanism of intracellular coenzyme A by pantothenate kinase in Archaea
| Project/Area Number |
19580079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Ibaraki University |
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Principal Investigator |
CHOHNAN Shigeru Ibaraki University, 農学部, 准教授 (70312775)
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| Project Period (FY) |
2007 – 2009
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| Keywords | パントテン酸キナーゼ / 古細菌 / コエンザイムA |
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| Research Abstract |
A gene encoding a pantothenate kinase (CoaA) which is a key enzyme in coenzyme A biosynthetic pathway has been identified in a thermoacidophilic archaeon. The archaeal CoaA belongs to a prokaryotic type I CoaA and is not governed by feedback inhibition by CoA and its thioesters, although prokaryotic type I CoaAs are generally inhibited by the CoA species. Therefore, CoA biosynthetic pathways in the archaea belonging to the order Thermoplasmatales which has the type I CoaA are not regulated at CoaA step.
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