2009 Fiscal Year Final Research Report
Mode of action of parasporin-4、a cytocidal protein from Bacillus thuringiensis.
| Project/Area Number |
19580117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Fukuoka Industrial Technology Center |
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Principal Investigator |
OKUMURA Shiro Fukuoka Industrial Technology Center, 生物食品研究所, 専門研究員 (40399671)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITOH Hiroyuki 福岡県工業技術センター, 生物食品研究所, 専門研究員 (60416493)
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| Project Period (FY) |
2007 – 2009
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| Keywords | Bacillus thuringiensis / がん細胞 / Parasporin |
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| Research Abstract |
Parasporin-4 (PS4) is a cytotoxic protein produced by Bacillus thuringiensis A1470 strain. It exhibits specific cytotoxicity against human cancer cell lines especially CACO-2、Sawano、and MOLT-4 cells. In this study、we subjected PS4 to the human cell lines and analyzed the PS4 and internal and external molecules of the cells. These results suggest that PS4 is a unique β-pore-forming toxin.
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