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2008 Fiscal Year Final Research Report

Analysis of specific structure of Clostridium botulinum C・D mosaic neurotoxins and the development of their detection methods

Research Project

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Project/Area Number 19580360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionOsaka Prefecture University

Principal Investigator

KOZAKI Shunji  Osaka Prefecture University, 生命環境科学研究科, 教授 (10109895)

Project Period (FY) 2007 – 2008
Keywordsボツリヌス症 / ボツリヌス毒素 / 受容体 / 診断法 / イムノクロマト
Research Abstract

鳥類や家畜のボツリヌス症由来菌の産生する「C・Dモザイク」毒素の特徴について、毒性と抗原性状を典型的なC型およびD型神経毒素と比較することにより明らかにした。特に最近、本邦で散発的に発生している牛ボツリヌス症由来菌について疫学的解析を行うとともに毒素の免疫学的手法を用いた迅速な特異検出方法の確立を試みた。

  • Research Products

    (6 results)

All 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D2008

    • Author(s)
      Tsukamoto, K., Kozai, Y., Ihara, H., Kohda, T., Mukamoto, M., Tsuji, T. and Kozaki, S.
    • Journal Title

      Microb Pathog. 44

      Pages: 484-493

    • Peer Reviewed
  • [Presentation] Characterization of Clostridium botulinum D/C mosaic neurotoxin associated with bovine botulism in Japan2008

    • Author(s)
      中村佳司
    • Organizer
      IBRCC2008
    • Place of Presentation
      アメリカ
    • Year and Date
      2008-08-14
  • [Presentation] Pathogenicity of botulinum C・D mosaic toxins in animals2008

    • Author(s)
      小崎俊司
    • Organizer
      TOXINS2008
    • Place of Presentation
      イタリア
    • Year and Date
      2008-06-13
  • [Presentation] 牛ボツリヌス症由来菌神経毒素に特異な抗原部位の検索と迅速診断法の確立2007

    • Author(s)
      幸田知子
    • Organizer
      日本細菌学会関西支部
    • Place of Presentation
      大阪府
    • Year and Date
      2007-11-10
  • [Presentation] 牛ボツリヌス症分離菌株産生毒素の性状解析2007

    • Author(s)
      中村佳司
    • Organizer
      第54回毒素シンポジウム
    • Place of Presentation
      大阪府
    • Year and Date
      2007-09-06
  • [Presentation] 牛ボツリヌス症由来菌株の毒素の性状と迅速診断法確立への試み2007

    • Author(s)
      小崎俊司
    • Organizer
      第143回日本獣医学会学術総会
    • Place of Presentation
      茨城県
    • Year and Date
      2007-04-03

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Published: 2010-06-10   Modified: 2016-04-21  

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