2009 Fiscal Year Final Research Report
Studies on the Molecular Mechanism of Species-specific Recognition in Biological Diversity
Project/Area Number |
19580395
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied molecular and cellular biology
|
Research Institution | Kyoto University |
Principal Investigator |
TANI Fumito Kyoto University, 地球環境学堂, 准教授 (70212040)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 分子情報 / ストレスタンパク質 / 多様性識別 / 種特異性 / 免疫生物学 |
Research Abstract |
Murine lymphoid neoplastic P388D1 cells were found to have six receptor candidates with the molecular sizes in the range from 130 to 300kDa which discriminate species-specificity among the C-terminal variable regions of heat shock protein 70 (HSP70). We revealed that species-specific diversity contributes in the cell-surface presentation on murine LL/2 lung carcinoma upon non-lethal heat shock, in the binding to CD11b-, CD11c-, or NK1.1-positive innate immune cells, and also in the differentiation to regulatory T cells from nalve T cells.
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Research Products
(15 results)