2009 Fiscal Year Final Research Report
Development of novel synthesis reactions based on radicals
| Project/Area Number |
19590005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
MIYABE Hideto Hyogo University of Health Sciences, 薬学部, 教授 (10289035)
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| Co-Investigator(Kenkyū-buntansha) |
KOHTANI Shigeru 兵庫医療大学, 薬学部, 講師 (00242529)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ラジカル |
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| Research Abstract |
Strategies involving cascade process offer the advantage of multiple carbon-carbon bond formations in a single operation. At first, we developed the radical cascade reaction of substrates having two different radical acceptors. Additionally, cascade reaction involving hydroxylation with molecular oxygen was also developed. Next, several reactions using catalysts were investigated. From the standpoint of sustainable chemistry, these developed catalyst-mediated reactions would be desirable tools for preparing organic compounds.
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