Development for preventive and therapeutic constituents on lifestyle diseases from spices

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: YOSHIKAWA Masayuki Kyoto Pharmaceutical University, 薬学部, 教授 (90116129)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Hisashi 京都薬科大学, 薬学部, 准教授 (40288593) ; NAKAMURA Seikou 京都薬科大学, 薬学部, 助教 (20411035)
• Project Period (FY): 2007 – 2008
• Keywords: 香辛料食品 / 伝承薬物 / 薬食同源 / 生活習慣病 / 抗肥満作用 / 抗糖尿病作用 / 作用機序 / 新規機能性成分

Research Abstract

本研究では, 薬食同源の視点から薬効が伝承されている天然薬物の中から香辛料食品に焦点を絞り, 新規機能性成分の開拓を行った. この研究過程で, 特にローズヒップ(Rosa canina)やナガコショウ(Piper chaba, 果実)の含有成分に強い抗肥満作用・抗糖尿病を有することを見いだすともに, 活性発現のための必須構造および作用機序の一部を明らかにした. また, 種々の香辛料食品から新規機能性成分を見いだした.

Research Products

• [Journal Article] Structures of new sesquiterpenes from Curcuma comosa (2008)
  • Author(s): Fengming Xu, Seikou Nakamura, Yang Qu, Hisashi Matsuda, Yutana Pongpiriyadacha, Lijun Wu, Masayuki Yoshikawa
  • Journal Title: Chem. Pharm. Bull. 56 Pages: 1710-1716
  • Peer Reviewed
• [Journal Article] Structures of new monoterpenes from Thai herbal medicine Curcuma comosa (2008)
  • Author(s): Seikou Nakamura, Yang Qu, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa
  • Journal Title: Chem. Pharm. Bull. 56 Pages: 1604-1606
  • Peer Reviewed
• [Journal Article] Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells (2008)
  • Author(s): Hailong Zhang, Hisashi Matsuda, Seikou Nakamura, Masayuki Yoshikawa
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 3272-3277
  • Peer Reviewed
• [Journal Article] Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-α-induced cell death in mouse hepatocytes (2008)
  • Author(s): Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Daisuke Yasuda, Itadaki Yamaguchi, Masayuki Yoshikawa
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 2038-2042
  • Peer Reviewed
• [Journal Article] Potent anti-obese principle from Rosa canina : Structural requirements and mode of action of trans-tiliroside (2007)
  • Author(s): Kiyofumi Ninomiya, Hisashi Matsuda, Mizuho Kubo, Toshio Morikawa, Norihisa Nishida, Masayuki Yoshikawa
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 3059-3064
  • Peer Reviewed
• [Journal Article] Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats (2007)
  • Author(s): Hisashi Matsuda, Momotaro Ochi, Akifumi Nagatomo, Masayuki Yoshikawa
  • Journal Title: Eur. J. Pharmacol 561 Pages: 172-181
  • Peer Reviewed
• [Presentation] タイ産ショウガ科植物のがん浸潤抑制および抗炎症活性成分-Zingiber cassumunar, Curcuma comosa, Curcuma zedoaria- (2008)
  • Author(s): 中村誠宏, 許鳳鳴, 浅尾恭伸, 李雪征, 中嶋聡一, 石見純子, 若山広子, 松田久司, 吉川雅之
  • Organizer: 第17回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 九州大学医学部百年講堂(福岡市)
  • Year and Date: 2008-11-14
• [Presentation] Antiobese and Gastroprotective Constituents from Several Spices (2007)
  • Author(s): Masayuki Yoshikawa, Hisashi Matsuda
  • Organizer: International Conference on Food Factors for Health Promotion-ICoFF2007-
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2007-11-29