2010 Fiscal Year Final Research Report
Development of in silico prediction technique for pharmaceutical design and optimization
| Project/Area Number |
19590045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
TAKAYAMA Kozo Hoshi University, 薬学部, 教授 (00130758)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 製剤設計 / 最適化 / スプライン / ブートストラップ |
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| Research Abstract |
A nonlinear response surface method incorporating thin-plate spline interpolation (RSM-S) was developed and applied to the designing a sustained release matrix tablet formulation. A bootstrap (BS) resampling method was employed to estimate confidence intervals of the optimal solution. As a result, the matrix tablet formulation with a constant release rate of the active ingredient for a long period was successfully optimized using RSM-S and the confidence interval of the optimal solution was adequately evaluated using BS.
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