2009 Fiscal Year Final Research Report
Developmental change, effects of stress and GIRK channel inhibitor on GIRK channel function.
| Project/Area Number |
19590069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHIRASAKI Tetsuya Kumamoto University, 大学院・生命科学研究部, 准教授 (30264047)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548)
SOEDA Fumio 熊本大学, 大学院・生命科学研究部, 助教 (10336216)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 薬理学 / K^+チャネル / 神経疾患 / 電気生理 |
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| Research Abstract |
To investigate the effects of early life stress on the functional change of GIRK channel in developing brain, rat pops were given maternal deprivation (MD) stress for 1h a day from postnatal day (PND) 2 to 14 or for 3 to 4h a day from PND2 to 9. As a result, the 5-HT-induced GIRK current (I_<5-HT>) was increased in hippocampal neurons. GIRK2 expression level was decreased in the hippocampus but not in prefrontal cortex and raphe nucleus. Anxiety level index in behavioral experiment was decreased. These suggest that MD stress affects the function of GIRK channel in the hippocampus.
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