2008 Fiscal Year Final Research Report
Molecular mechanisms and roles of cortical thin vessels on regulation of activity-dependent cerebral blood flow changes
| Project/Area Number |
19590203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
YAMADA Katsuya Hirosaki University, 大学院・医学研究科, 准教授 (40241666)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masahiko 北海道大学, 大学院・医学研究科, 教授 (70210945)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 脳血流調節 / 活動依存性 / ATP / Kチャネル |
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| Research Abstract |
脳血流は、神経活動に応じて局所的に調節されるが、この調節を司る脳内細血管のタイプと時間的な血流変化の関係などの詳細はわかっていない。血管平滑筋型ATP感受性カリウム(K_<ATP>)チャネルのサブユニットKir6.1を欠失させたマウスの実験から、神経活動に対応する脳血流調節に脳内の特定の細動脈の拡張が関わることがわかり、更に議論のあったKir6.1の脳内局在についてもmRNAレベルでは一定の結論が得られた。
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[Journal Article] Predominant expression of phospholipase Cb1 in telencephalic principal neurons and cerebellari nterneurons, and its close allocation with related signaling molecules in somatodendritic neuronal elements2008
Author(s)
Fukaya, M., Uchigashima, M., Nomura, S., Hasegawa, Y., Kikuchi, H., Watanabe, M.
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Journal Title
Eur.J.Neurosci 28
Pages: 1744-1759
Peer Reviewed
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[Journal Article] Synthesis of 2-NBDLG, a fluorescent derivative of L-glucosamine; the antipode of D-glucose tracer 2-NBDG2008
Author(s)
Yamamoto, T., Nishiuchi, Y., Teshima, T., Matsuoka, H., and Yamada, K.
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Journal Title
Tetrahedron Lett. 49
Pages: 6876-6878
Peer Reviewed
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[Journal Article] Glutamate transporters regulate lesion-induced period plasticity in the developing somatosensory cortex2008
Author(s)
Takasaki, C., Okada, R., Mitani, A.,Fukaya, M., Yamasaki, M., Fujihara, Y.,Shirakawa, T., Tanaka, K., Watanabe,M.
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Journal Title
J. Neurosci 28
Pages: 4995-5006
Peer Reviewed
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[Journal Article] Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IE1802008
Author(s)
Tomioka, Y,. Miyazaki, M., Taharaguchi, S., Yoshino, S., Morimatsu, M., Uede, T., Ono, E., Watanabe, M.
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Journal Title
Eur.J.Neurosci 27
Pages: 2115-2132
Peer Reviewed
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[Journal Article] ABCA2 deficiency resultsin abnormal sphingolipid metabolismin mouse brain2007
Author(s)
Sakai, H., Tanaka, Y., Tanaka, M., Ban, N., Yamada, K., Matsumura, Y.,Watanabe d., Sasaki, M., Kita, T., Inagaki, N.
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Journal Title
J.Biol.Chem 282
Pages: 19692-19699
Peer Reviewed
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[Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice2007
Author(s)
Miyake, A., Yamada, K., Kosaka, T.,Miki, T., Seino, S., Inagaki, N.
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Journal Title
Eur.J.Neurosci 25
Pages: 2349-2363
Peer Reviewed
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[Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum2007
Author(s)
Uchigashima,M., Narushima,M., Fukaya,M., Katona,I., Kano,M., Watanabe, M.
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Journal Title
J.Neurosci 27
Pages: 3663-3676
Peer Reviewed
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[Presentation] Ultrastructural localization ofglycine transporters in thesubstantia nigra pars reticulata ofthe rat2009
Author(s)
Watanabe, N., Yamada, K., Suga, S., Yamada, M., Yamamoto, Y.
Organizer
114th Annual Meeting of TheJapanese Association of Anatomists
Place of Presentation
Okayama, Japan
Year and Date
20090328-30
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