2010 Fiscal Year Final Research Report
Basic research for development of CTL-inducible vaccine against West Nile virus using recombinant E protein
Project/Area Number |
19590604
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Kinki University |
Principal Investigator |
MASAKI Hideyuki Kinki University, 医学部, 講師 (90247982)
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Co-Investigator(Renkei-kenkyūsha) |
KONISHI Eiji 神戸大学, 大学院・保健学研究科, 准教授 (40135786)
|
Research Collaborator |
SATOH Mayumi 神戸大学, 大学院・保健学研究科, 大学院生
KUWAHARA Miwa 神戸大学, 大学院・保健学研究科, 大学院生
|
Project Period (FY) |
2007 – 2010
|
Keywords | ウエストナイルウイルス / E蛋白質 / 成分ワクチン / 組換えワクチン / CTL / cross-presentation / 中和抗体 / 感染防御 |
Research Abstract |
West Nile virus (WNV) is the human-infectious virus, which sometimes causes lethal encephalitis/meningitis, and the vaccine for human use has not been developed yet. Based on the findings concerning its relative viruses, it is anticipated that the envelope (E) protein should induce protective immunity. In the present study, we have established several recombinant WNV E protein expression systems and the CTL target cells in order to develop the recombinant component vaccine against WNV infection, which induces not only neutralizing antibody but also CTL, using recombinant WNV E protein combined with cross-presentation inducing adjuvant.
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