2009 Fiscal Year Final Research Report
Cardiac Dendritic Cell and Its Activation Mechanism
| Project/Area Number |
19590830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
IZUMI Toru Kitasato University, 医学部, 教授 (80143775)
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Takayuki 北里大学, 医学部, 講師 (20311954)
TAKEHANA Hitoshi 北里大学, 医学部, 助教 (30296446)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 反応性T細胞 / 心臓樹状細胞 |
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| Research Abstract |
Cardiac autoimmunity is an attractive scenario among cardio-immunologists. It well explains a pathomechanisms of dilated cardiomyopathy. Thus, employing a cardiac specific protein, cardiac myosin, a unique rat model of experimental autoimmune myocarditis/cardiomyopathy (EAM) has been established. Cell-mediated immunity by the T lymphocyte is essentially working in this model. To our best knowledge, identification of the T cell epitope, establishing myosin autoreactive T cell line and provoking myocarditis by transfer of this cell line into healthy rat have been already achieved. At the present time, to investigate further mechanism of the cell-mediated immunity, it requires cellular labeling of the target cell including the cardiac dendritic cell. By applied bioengineering of GFP expression transgenic rat, presently the following studies are developing, (1) dynamical observation on immune cells which provoke myocarditis/cardiomyopathy, (2) EAM transferred by GFP expression myocarditogenic T lymphocyte and histological identification of the immune cells in situ.
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