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2008 Fiscal Year Final Research Report

Role of macrophage migration inhibitory factor on the progression of the aortic aneurysm

Research Project

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Project/Area Number 19590846
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

FUKUZAWA Jun  Asahikawa Medical College, 医学部, 特任准教授 (40333695)

Project Period (FY) 2007 – 2008
Keywordsマクロファージ / 弾性血管 / ELISA
Research Abstract

腹部大動脈瘤形成モデルの確立 : 野生型マウスに対して大動脈瘤作製処置を行い、大動脈径の拡大を観察した。瘤形成部位におけるMIF発現および血中MIF濃度を確認した。MIFの発現細胞をメッセージレベルおよび蛋白レベルで検討した。腹部大動脈瘤作製法 : 3種類の方法を検討した(塩化カルシウム刺激法、アンジオテンシンII注入法、ApoEノックアウトマウス法)。塩化カルシウム刺激法が濃度依存性などの関係で本実験系に適していることがわかった。

  • Research Products

    (4 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Immunolocalization of a novel collectin CL-K1 in murine tissues2008

    • Author(s)
      Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J, Mori K, Jang S, Nomura N, Yoshida I, Suzuki Y, Kohgo Y, Wakamiya N
    • Journal Title

      Journal of Histochemistry and Cytochemistry 56

      Pages: 243-52

    • Peer Reviewed
  • [Journal Article] Scavenger receptor CL-P1 predominantly mediates zymosan phagocytosis by human vascular endothelial cells2008

    • Author(s)
      Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 3956-3965

    • Peer Reviewed
  • [Presentation] Circulating oxidized LDL levels and blood pressure in patients with hemodialysis2008

    • Author(s)
      Fukuzawa J., Yao N., Hasebe N., Itabe H., Jang S., Ohtani K., Wakamiya N.
    • Organizer
      The 22nd Scientific meeting of the International Society of Hypertension The 22nd Scientific meeting of the International Society of Hypertension
    • Place of Presentation
      Berline, Germany
    • Year and Date
      2008-06-16
  • [Book] 高血圧性臓器障害の評価、「高血圧診療ハンドブックエビデンスに基づく、食事・運動・薬物療法の進め方」(浦信行編集)2008

    • Author(s)
      福澤純、長谷部直幸
    • Total Pages
      263
    • Publisher
      羊土社

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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