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2008 Fiscal Year Final Research Report

A novel therapeutic strategy for glucocorticoid-induced vascula endothelial dysfundtion

Research Project

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Project/Area Number 19590866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

AKAIKE Masashi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (90271080)

Co-Investigator(Kenkyū-buntansha) AIHARA Ken-ihchi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372711)
IWASE Takashi  徳島大学, 医学部・歯学部附属病院, 助教 (10403718)
Project Period (FY) 2007 – 2008
Keywords血管内皮機能 / 酸化ストレス / 活性酸素 / 一酸化窒素 / 一酸化窒素合成酵素 / グルココルチコイド / スタチン
Research Abstract

グルココルチコイド過剰マウスでは, 血圧上昇、血管内皮機能低下, 酸化ストレス増加、一酸化窒素産生低下がみられ, これらはピタバスタチンにより改善した. 培養ヒト臍帯静脈血管内皮細胞では, ピタバスタチンはデキサメサゾンによる活性酸素産生の増加と内皮型一酸化窒素合成酵素の発現低下を改善し、この作用はイソプレノイド中間体であるゲラニルゲラニルピロリン酸により完全に消失した. ピタバスタチンは血管内皮細胞に対する多面的作用により, グルココルチコイド誘発性血管障害の新規治療法となる可能性がある.

  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] ステロイド投与下におけるスタチンと血管内皮2009

    • Author(s)
      赤池雅史, 松本俊夫
    • Journal Title

      災害外科 (in press)

  • [Journal Article] Heparin cofactor II, a novel vascular remodeling factor : its clinical significance and molecular pathogenesis in atherosclerosis2009

    • Author(s)
      Aihara K, Azuma H, Akaike M, Sata M, Matsumoto T
    • Journal Title

      J Atheroscier Thromb (in press)

    • Peer Reviewed
  • [Journal Article] Heparin Cofactor II Is an Independent Protective Factor Against Peripheral Arterial Disease in Elderly Subjects With Gardiovascular Risk Factors2009

    • Author(s)
      Aihara K, Azuma H, Akaike M, Kurobe H, Sumitomo Y, Yoshida S, Ise T, Iwase T, Ishikawa K, Sata M, Kitagawa T, Matsumoto T
    • Journal Title

      J Atherascler Thramb (in press)

    • Peer Reviewed
  • [Journal Article] Androgen-Androgen Receptor System Protects against Angiotensin II-Induced Vascular Remodeling2009

    • Author(s)
      Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, Akaike M, Kato S, Matsumoto T
    • Journal Title

      Endcrinology 150(6)

      Pages: 2857-2864

    • Peer Reviewed
  • [Journal Article] Infective endocarditis caused by lactobacillus2008

    • Author(s)
      Yagi S, Akaike M, Fujimura M, Ise T, Yoshida S, Sumitomo Y, Ikeda Y, Iwase T, Aihara K, Azuma H, Kurushima A, Ichikawa Y, Kitagawa T, Kimura T, Nishiuchi T, Matsumoto T
    • Journal Title

      Intern Med 47(12)

      Pages: 1113-6

    • Peer Reviewed
  • [Journal Article] Impact of serum insulin-like growth factor-1 on early prognosis in acute myocardial infarction2008

    • Author(s)
      Yamaguchi H, Komamura K, Choraku M, Hirono A, Takamori N, Tamura K, Akaike M, Azuma H
    • Journal Title

      Intern Med 47(9)

      Pages: 819-25

    • Peer Reviewed
  • [Journal Article] Pitavastatin, an HMG-CoA Reductase Inhibitor, Exertse NOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency2008

    • Author(s)
      Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Yoshida S, Ise T, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T
    • Journal Title

      Circ Res 102(1)

      Pages: 68-76

    • Peer Reviewed
  • [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice2007

    • Author(s)
      Aihara K, Azuma H, Akaike M, Ikeda Y, Sata M, Takamori N, Yagi S, Iwase T, Sumitomo Y, Sato T, Nakamichi Y, Yamamoto Y, Yoshimora K, Watanabe T, Nakamura T, Oomizu A, Tsukada M, Hayashi H, Sudo T, Kato S, Matsumoto T
    • Journal Title

      J Clin Invest 117

      Pages: 1486-9

    • Peer Reviewed
  • [Journal Article] ステロイド過剰によるNO bioavailabilityの低下と血管内皮機能障害2007

    • Author(s)
      赤池雅史, 松本俊夫
    • Journal Title

      CLINICAL CALCIUM 17(6)

      Pages: 864-870

  • [Presentation] Pitavastatin excretese NOS-independent protective action against angiotensin II-induced atrial remodeling through attenuating Rac1-mediated oxidative stress 73^<th> Annual Scientific Meeting of the Japanese2009

    • Author(s)
      Yagi S, Akaiice M, Aihara K, Ishikawa K, Ise T, Yoshida S, Sumitomo Y, Ikeda Y, Iwase T, Soeki T, Matsumoto T, Sata M
    • Organizer
      Circulation Society
    • Place of Presentation
      Osaka
    • Year and Date
      20090320-22
  • [Presentation] Anovele NOS-independent protective action of statin against angiotensin II-inducedatrial remodeling via attenuating Rac-1-mediaked oxidative stress2008

    • Author(s)
      Yagi S, Akaike M, Aihara K, Ishikawa K, Ise T, Yoshida S, Sumitomo Y, Ikeda Y, Iwase T, Soeki T, Matsumoto T, Sata M
    • Organizer
      American Heart Association 2008
    • Place of Presentation
      New Orleans, America
    • Year and Date
      20081108-12
  • [Presentation] ピタバスタチンはERK5-KLF2経路の活性化を介して血管内皮細胞での一酸化窒素合成酵素の発現を亢進する2008

    • Author(s)
      赤池雅史, 八木秀介, 粟飯原賢一, 石川カズ江, 池田康将, 吉田守美子, 住友由佳, 岩瀬俊, 阿部純一, 松本俊夫, 佐田政隆
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      20081009-11
  • [Presentation] Pitavastatin, an HMG-CoA Rednctase Inhibitor, Prevents Glucocorticaid-induced Hypertension through Increased Nitric Oxide Production as a Pleiotropic Effect on Vascular Endothelial Cells2008

    • Author(s)
      Akaike M, Aihara K, Yagi S, Ikeda Y, Ichikawa K, Ise T, Yoshida S, Sumitomo Y, Iwase T, Matsumoto T
    • Organizer
      22nd Scienkific Meeting of the International Society of Hypertension Berlin
    • Place of Presentation
      Germany
    • Year and Date
      20080614-19
  • [Presentation] HMG-CoA Reductase Inhibitor Pitavastatin Increases the Expression of Endothelial NOS through Activation of EIZK5-KLF2 Pathway in Vascular Endothelial Cells2008

    • Author(s)
      Akaike M, Yagi S, Aihara K, Ikeda Y, Ishikawa K, Ise T, Yoshida S, Sumitpmo Y, Iwase T, Abe J, Matsumoto T
    • Organizer
      72^<th> Annual Scientific Meething of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      20080328-30
  • [Presentation] グルココルチコイド誘発性高血圧に対するピタバスタチンの効果とその機序の検討2007

    • Author(s)
      赤池雅史, 粟飯原賢一, 八木秀介, 池田康将, 石川カズ江、住友由佳, 岩瀬俊, 松本竣夫
    • Organizer
      第30回日本高血圧学会学総会
    • Place of Presentation
      宜野湾市
    • Year and Date
      20071025-27
  • [Presentation] 「大腿骨頭壊死症の病態解明」ステロイド性骨壊死と血管内皮障害2007

    • Author(s)
      赤池雅史シンポジウム
    • Organizer
      第34回日本股関節学会
    • Place of Presentation
      金沢市
    • Year and Date
      2007-10-11

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Published: 2010-06-10   Modified: 2016-04-21  

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