2009 Fiscal Year Final Research Report
Where is the cause of Bartter's syndrome in the kidney?
| Project/Area Number |
19590936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WATANABE Sumiyo The University of Tokyo, 医学部附属病院, 医員 (30422314)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Taku 東京大学, 医学部附属病院, 特任助教 (30456107)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Tosiyuki 東京大学, 医学部附属病院, 助教 (80322759)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
UCHIDA Shunya 帝京大学, 医学部, 教授 (50151882)
SUZUKI Nobuchika 東京大学, 先端科学技術研究センター, 特任助教 (90247007)
HONDA Zenitiro 東京大学, 医学部附属病院, 講師 (70238814)
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| Project Period (FY) |
2007 – 2009
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| Keywords | バーター症候群 / カルシウム代謝 / 腎機能低下 / 副甲状腺機能低下症 |
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| Research Abstract |
We developed the expression method using tissue-specific promoters and it resulted in site-specific EGFP expression within the kidney. Adenovirus expression could be limited to the thick ascending limb of Henle (TALH), proximal tubules, or collecting ducts of the kidney without causing liver expression or kidney damage. We investigated it using GFP protein, and next, we tend to express calcium-sensing receptor.
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Research Products
(18 results)
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[Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p572009
Author(s)
Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, et.al.
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Journal Title
PLoS One. 4(2)(Epub)
Pages: e4543
Peer Reviewed
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[Journal Article] Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes2008
Author(s)
Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, et.al.
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Journal Title
J Clin Invest. 118(7), Erratum in 118(8)
Pages: 2506-15, Erratum in 2986
Peer Reviewed
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