2008 Fiscal Year Final Research Report
Integrative study on the biological response modifications by arginine-related molecules including NO and ADMA
Project/Area Number |
19591201
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | University of Fukui |
Principal Investigator |
TSUKAHARA Hirokazu University of Fukui, 医学部・附属病院, 講師 (90207340)
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Project Period (FY) |
2007 – 2008
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Keywords | 成育医学 |
Research Abstract |
生体にはL-arginine/NO synthase/NO系とprotein-arginine methyltransferase(PRMT)/ADMA/dimethylarginine dimethylaminohydrolase(DDAH)系が並立し、相互作用しながら血管機能・酸化還元環境を制御することを、様々な小児患者を対象に複数のバイオマーカーを計測することで示した。
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Research Products
(36 results)
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[Journal Article] Sustaining hypercitrullinemia, hypercholesterolemia and augmented oxidative stress in Japanese children with aspartate/glutamate carrier isoform 2-citrin- deficiency even during the silent period2009
Author(s)
Nagasaka H, Okano Y, Tsukahara H, Shigematsu Y, Momoi T, Yorifuji J, Miida T, Ohura T, Kobayashi K, Saheki T, Hirano K, Takayanagi M, Yorifuji T
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Journal Title
Mol Genet Metab 97(1)
Pages: 21-26
Peer Reviewed
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[Journal Article] Evaluation of endogenous nitric oxide synthesis in congenital urea cycle enzyme defects2009
Author(s)
Nagasaka H, Tsukahara H, Yorifuji T, Miida T, Murayama K, Tsuruoka T, Takatani T, Kanazawa M, Kobayashi K, Okano Y, Takayanagi M
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Journal Title
Metabolism 58(3)
Pages: 278-282
Peer Reviewed
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[Journal Article] Effects of bezafibrate on dyslipidemia with cholestasis in children with familial intrahepatic cholestasis-1 deficiency manifesting progressive familial intrahepatic cholestasis2009
Author(s)
Nagasaka H, Yorifuji T, Hirano K, Ota A, Toyama-Nakagawa Y, Takatani T, Tsukahara H, Kobayashi K, Takayanagi M, Inomata Y, Uemoto S, Miida T
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Journal Title
Metabolism 58(1)
Pages: 48-54
Peer Reviewed
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[Journal Article] Clinical significance of the balance between the L-arginine/NOS/NO pathway and the PRMT/ADMA/DDAH pathway2008
Author(s)
Tsukahara H, Ohta N, Tokuriki S, Tamura S, Toyo-oka M, Nishijima K, Orisaka M, Kotsuji F, Ohta N, Kawakami H, Sekine K, Nagasaka H, Mayumi M
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Journal Title
J Dev Nephrol 16(1)
Pages: 21-28
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[Journal Article] Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome2008
Author(s)
Nagasaka H, Miida T, Hirano K, Ota A, Murayama K, Yorifuji T, Kobayashi K, Takatani T, Tsukahara H, Hui SP, Takayanagi M, Chiba H
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Journal Title
Atherosclerosis 198(2)
Pages: 434-440
Peer Reviewed
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[Journal Article] Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life2008
Author(s)
Nagasaka H, Miida T, Hirano K, Ota A, Yorifuji T, Takatani T, Tsukahara H, Takayanagi M, Hui SP, Kobayashi K, Chiba H
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Journal Title
J Clin Endocrinol Metab 93(3)
Pages: 779-783
Peer Reviewed
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[Journal Article] Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood2008
Author(s)
Tsukahara H, Ohta N, Tokuriki S, Nishijima K, Kotsuji F, Kawakami H, Ohta N, Sekine K, Nagasaka H, Mayumi M
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Journal Title
Metabolism 57(2)
Pages: 215-220
Peer Reviewed
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[Journal Article] 動脈管早期閉鎖により新生児遷延性肺高血圧症をきたした1例2008
Author(s)
巨田尚子, 田村知史, 徳力周子, 小倉一将, 畑郁江, 塚原宏一, 鈴木千代, 西島浩二, 折坂誠, 小辻文和, 眞弓光文
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Journal Title
小児科臨床 61(8)
Pages: 1685-1689
Peer Reviewed
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[Journal Article] Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis2007
Author(s)
Nagasaka H, Chiba H, Hui SP, Takikawa H, Miida T, Takayanagi M, Yorifuji T, Hasegawa M, Ota A, Hirano K, Kikuchi H, Tsukahara H, Kobayashi K
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Journal Title
J Pediatr Gastroenterol Nutr 45(1)
Pages: 96-105
Peer Reviewed
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[Journal Article] Procedures for prevention of perinatal group B streptococcal diseases : A multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan2007
Author(s)
Matsubara K, Kawai M, Nakahata T, Kato F, Tsukahara H, Yamakawa M, Hashimoto K, Shimada S, Maeda S, Okumura M, Kanaoka H
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Journal Title
J Infect Chemother 13(1)
Pages: 59-62
Peer Reviewed
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[Journal Article] Nitric oxide metabolism in asymptomatic preschool children with congenital anomalous portal veins presenting porto-systemic venous shunt flow
Author(s)
Takatani T, Nagasaka H, Sugamoto K, Aizawa M, Miida T, Yorifuji T, Tajima G, Sakura N, Murayama K, Sanayama T, Okano Y, Mayumi M, Kobayashi K, Hirano K, Takayanagi M, Tsukahara H
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Journal Title
Metabolism 2009 (in press)
Peer Reviewed
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[Journal Article] Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and I14A, during the first year of life
Author(s)
Nagasaka H, Yorifuji T, Momoi T, Yorifuji J, Hirano K, Ota A, Takatani T, Tsukahara H, Takayanagi M, Kobayashi K, Chiba H, Sato Y, Miida T
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Journal Title
Clin Chim Acta 2009 (in press)
Peer Reviewed
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[Presentation] Activating mutation of heme oxygenase(HO)-1 : A novel disease entity characterized by microcytic, hemolytic anemia, a defect of bilirubin synthesis and hereditary hemophagocytic lymphohistiocytosis2007
Author(s)
Greil J, Verga-Falzacappa M, Tsukahara H, Behnisch W, Heimpel H, Schneider M, Janka G, Claus M, Muckenthaler M, Kulozik AE
Organizer
49th Annual Meeting of American Society of Hematology
Place of Presentation
Georgia, USA
Year and Date
20071200
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[Presentation] ヒトにおけるL-arginine/NOS/NO系とPRMT/ADMA/DDAH系のバランスの生理学的意義について2007
Author(s)
塚原宏一, 巨田尚子, 田村知史, 眞弓光文, 西島浩二, 折坂誠, 小辻文和, 長坂博範, 川上寿子, 太田徳仁, 関根恭一
Organizer
第16回発達腎研究会
Place of Presentation
東京
Year and Date
20070800
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