2009 Fiscal Year Final Research Report
Study of expression and physiological function of ARTEMIN, a family of glial cell line derived neurotrophic factor family, in skin
| Project/Area Number |
19591304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
MUROTA Hiroyuki Osaka University, 医学系研究科, 助教 (90363499)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 皮膚生理学 |
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| Research Abstract |
We focused on de novo synthesis of artemin (ARTN), which is a member of the glial cell line-derived neurotrophic factor related family, gene transcription in dermal fibroblast after substance P (SP)-stimulation. ARTN was accumulated in dermis of AD skin lesions, while not in that of psoriasis and healthy controls. SP-treated dermal fibroblast-derived artemin can be assumed to contribute to peripheral nerve sprouting. Furthermore, we found that ARTN contributed to development of SP-induced thermal hyperalgesia and compound 48/80-induced itch. From these results, we placed more expectations on ARTN for therapeutic target of intractable itch.
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