2009 Fiscal Year Final Research Report
Functional analysis of primary cilia in the CNS using pericentrin mutant mice
Project/Area Number |
19591355
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Okayama University |
Principal Investigator |
MIYOSHI Ko Okayama University, 大学院・医歯薬学総合研究科, 助教 (90362996)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 繊毛 / 中心体 / 中枢神経系 |
Research Abstract |
Mice homozygous for a mutation in pericentrin gene displayed malformation of primary cilia in the CNS and olfactory cilia of olfactory receptor neurons. There was no significant difference in locomotion, anxiety-related behavior and neurogenesis in the subgranular zone of hippocampal dentate gyrus between homozygous mutant mice and wild-type mice. On the other hand, the mutant mice displayed behavioral alterations of an anti-depressive phenotype in addition to reduced olfactory performance, suggesting malformation of primary cilia in the CNS led to an anti-depressive effect.
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Research Products
(10 results)