2008 Fiscal Year Final Research Report
The development of the quality evaluation system of gene-modified dendritic cells for cancer immunotherapy and gene therapy
Project/Area Number |
19591504
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
KATANO Hisako The University of Tokyo, 医科学研究所, 特任助教 (50376620)
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Co-Investigator(Kenkyū-buntansha) |
TAHARA Hideaki 東京大学, 医科学研究所, 教授 (70322071)
SASAKI Katsunori 東京大学, 医科学研究所, 研究拠点形成特任教員 (60336394)
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Project Period (FY) |
2007 – 2008
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Keywords | トランスレーショナルリサーチ / ウイルスベクター / 遺伝子治療 / 細胞療法 / 樹状細胞 / 免疫学 |
Research Abstract |
Virus-mediated delivery of therapeutic genes into dendritic cells(DCs) is a promising method for cancer immunotherapy. As there is not the public standard that determined the quality of the gene-modified DCs as the clinical experimental drug, it is the present conditions that the quality of gene-modified DCs is left to the judgment of each the enforcement organization. To develop the quality evaluation system of the gene-modified dendritic cells which are the final product, we clarified quality and stability of a vector/cells which are correspond to raw materials, then examined a method of gene transfer into dendritic cells.
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Research Products
(3 results)
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[Presentation]2009
Author(s)
佐藤まりも, 金本彰, 地主将久, 片野尚子, 米山公康, 伊藤精彦, 田原秀晃
Organizer
第13回日本がん免疫学会総会
Year and Date
20090624-20090625