2009 Fiscal Year Final Research Report
Establishment of minimal invasive treatment system for breast cancer using real-time MRI navigation
Project/Area Number |
19591506
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Shiga University of Medical Science |
Principal Investigator |
SHIMIZU Tomoharu Shiga University of Medical Science, 医学部, 助教 (70402708)
|
Co-Investigator(Kenkyū-buntansha) |
MURATA Satoshi 滋賀医科大学, 医学部, 助教 (90239525)
ABE Hajime 滋賀医科大学, 医学部, 助教 (80283563)
ENDO Yoshihiro 滋賀医科大学, 医学部, 講師 (40263040)
KURUMI Yoshimasa 滋賀医科大学, 医学部, 講師 (70205219)
TANI Tohru 滋賀医科大学, 医学部, 講師 (20179823)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 乳腺外科学 |
Research Abstract |
The aim of this study is to establish minimal invasive treatment system for breast cancer using real-time MRI navigation. We performed MR-guided microwave coagulation therapy against breast cancer before total mastectomy under patients' agreement. We confirmed the safety and feasibility of breast tumor ablation in human body. Patient was set spine position in the Open MR under general anesthesia. We were able to observe the position of tumor by real time MR image and insert ablation needle into the tumor watching real time monitor. Tumors were ablated on one session (60W, 60seconds × 3times). Thereafter total mastectomy was performed. The resected specimens were evaluated macroscopic and microscopic examination. The ablated area was confirmed as approximately 20×30 mm. The viability of tumor was disappeared in this ablated area by NADH staining. There was no complication observed in the skin. Our finding suggested the microwave coagulation therapy might be safe and feasible to treat breast cancer in the human body. We were able to confirm basic information to apply clinical trial in the near future.
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Research Products
(6 results)
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[Presentation] 開放型MRナビゲーションによる乳癌温存治療の臨床研究2009
Author(s)
清水智治, 阿部元, 遠藤善裕, 目片英治, 山本寛, 村田聡, 塩見尚礼, 仲成幸, 森毅, 梅田朋子, 山口剛, 来見良誠, 森川茂廣, 谷徹
Organizer
第34回日本外科系連合学会学術集会
Place of Presentation
東京
Year and Date
2009-06-18
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[Presentation] 乳癌に対するMRガイド下マイクロ波凝固療法の検討2008
Author(s)
清水智治, 阿部元, 村田聡, 張弘富, 河合由紀, 村上耕一郎, 村山浩之, 田中麻紀子, 森川茂廣, 来見良誠, 谷徹
Organizer
第16回日本乳癌学会総会
Place of Presentation
大阪
Year and Date
2008-09-26
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[Presentation] 乳房温存治療としてのリアルタイムMRIガイド下マイクロ波凝固療法の可能性2007
Author(s)
清水智治, 来見良誠, 阿部元, 遠藤善裕, 村田聡, 目片英治, 塩見尚礼, 仲成幸, 山本寛, 森川茂廣, 谷徹
Organizer
第45回日本癌治療学会総会学術集会
Place of Presentation
京都国際会議
Year and Date
2007-10-24
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[Presentation] リアルタイムMRIガイド下マイクロ波凝固療法による乳癌治療の可能性2007
Author(s)
清水智治, 来見良誠, 遠藤善裕, 村田聡, 目片英治, 阿部元, 仲成幸, 塩見尚礼, 山本寛, 内藤弘之, 出村公一, 森川茂廣, 谷徹
Organizer
第107回日本外科学会定期学術集会
Place of Presentation
大阪
Year and Date
2007-04-12