2009 Fiscal Year Final Research Report
In vivo real time imaging of esophageal cancer with CdSe nanoparticle
| Project/Area Number |
19591527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KAMEI Takashi Tohoku University, 病院, 助教 (10436115)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Go 東北大学, 大学院・医学系研究科, 講師 (60282076)
TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808)
OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
SATOMI Susumu 東北大学, 病院, 教授 (00154120)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Masaki 東北工業大学, 工学部, 教授 (90332981)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食道癌 / CdSeナノクリスタル / 蛍光計測 / リアルタイムイメージング / センチネルリンパ節 / 蛍光内視鏡手術 |
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| Research Abstract |
We developed ultra-stable nanoparticles of CdSe conjugated with anti-Her2 antibody as a novel functional fluorescent probe for in vivo imaging. After intravenous injection of this nanoparticle, we were able to detect the fluorescent signals and image of human esophageal cancer in tumor-bearing nude mouse from outside the body successfully. Furthermore, we developed new surgical system for endoscopic fluorescent surgery based on clinical application. Using this fluorescent detection system and CdSe as a nano-tracer, we succeeded in real time imaging of lymph networks and sentinel lymph node biopsy of gastrointestinal tract in pig model.
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