2010 Fiscal Year Final Research Report
Establishment of simultaneous islet cell and pancreas transplantation from a splitting single-donor pancreas
| Project/Area Number |
19591588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
MATSUMOTO Ippei Kobe University, 医学部附属病院, 講師 (30379408)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Toshiaki 神戸大学, 医学部附属病院, 医員 (30403249)
SHINZEKI Makoto 神戸大学, 大学院・医学研究科, 助教 (60444593)
HORI Yuichi 神戸大学, 大学院・医学研究科, 准教授 (80248004)
KURODA Yoshikazu 神戸大学, 医学研究科, 名誉教授 (70178143)
KU Yonson 神戸大学, 大学院・医学研究科, 教授 (40195615)
TOYAMA Hirochika 神戸大学, 大学院・医学研究科, 助教 (10444598)
TANIOKA Yasuki 神戸大学, 医学研究科, COE研究員 (00372649)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 膵島移植 / 膵臓移植 / 移植外科学 / 二層法 |
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| Research Abstract |
We have developed a two-layer pancreas preservation method, which supplies oxygen during preservation, and reported efficacy of its use for pancreas and islet cell transplantation. We apply this concept (oxygenation) to the islet isolation process to obtain more islets. We investigated the efficacy of oxygenation during pancreas digestion process (A), low pressure-controlled injection of collagenase (B) and oxygenation on isolated islets during transportation (C). Islet yield and function were improved in protocol A and B. However, there was no advantage in protocol C.
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[Journal Article] Improved quantity and in vivo function of islets isolated by reduced pressure-controlled injection of collagenase in a rat model.2007
Author(s)
Li S, Sakai T, Suzuki Y, Goto T, Tanaka T, Yoshikawa T, Kakinoki K, Tanioka Y, Matsumoto I, Fujino Y, Kuroda Y.
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Journal Title
Cell Transplantation 16(5)
Pages: 539-545
Peer Reviewed
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[Journal Article] Applictaion of the two-layler method on pancreas digestion results in improved islet yield and maintained viability of isolated islets.2007
Author(s)
Goto T, Tanioka Y, Sakai T, Terai S, Kamoda Y, Li S, Tsujimura T, Matsumoto I, Fujino Y, Suzuki Y, Kuroda Y.
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Journal Title
Transplantation 83(6)
Pages: 754-758
Peer Reviewed
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