2009 Fiscal Year Final Research Report
Establishment of Immunosuppressive Therapy by Regulatory T cells Induced Type V Collagen with Immunosuppressive Medication
| Project/Area Number |
19591612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHIDA Shigetoshi Chiba University, 医学部附属病院, 講師 (90334200)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Ichiro 千葉大学, 大学院・医学研究院, 教授 (40281547)
WADA Hironobu 千葉大学, 医学部附属病院, 医員 (90514604)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKINE Yasuo 東京女子医科大学, 医学部, 准教授 (70312957)
YASUFUKU Kazuhiro University Health Network, Toronto, Canada, Division of Thoracic surgery, Toronto General Hospital, Assistant Professor (60372356)
SUZUKI Hidemi 東京女子医科大学, 医学部, 助教 (60422226)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 呼吸器外科学 / 移植・再生医療 / 外科 / 免疫学 / 細胞・組織 |
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| Research Abstract |
Oral administration of type V collagen [col(V)] plus low-dose cyclosporine (CsA) was abrogates rejection of fully MHC incompatible rat lung allograft. Col(V) plus CsA was down-regulated alloantigen-induced production of IFN-gamma and IL-17A and associated with alloantigen-induced expression of IL-10 in recipient T cells. These data demonstrate that col(V) enhances low-dose CsA-mediated immune suppression, and suggest a role for oral col(V) in immune modulation in lung transplantation.
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[Journal Article] Lung transplant ischemia reperfusion injury : Metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-[alpha] expression2008
Author(s)
Iwata T, Chiyo M, Yoshida S, Smith GN Jr., Mickler EA, Presson R Jr., Fisher AJ, Brand DD, Cummings OW, Wilkes DS
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Journal Title
Transplantation Vol 85
Pages: 417-426
Peer Reviewed
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[Journal Article] Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung2008
Author(s)
Chiyo M, Iwata T, Webb TJ, Vasko MR, Thompson EL, Heidler KM, Cummings OW, Yoshida S, Fujisawa T, Brand DD, Wilkes DS
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Journal Title
American Journal of Transplantation Vol 8
Pages: 537-546
Peer Reviewed
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[Journal Article] IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants2007
Author(s)
Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Haynes MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS
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Journal Title
Journal of Clinical Investigation Vol 117
Pages: 3498-3506
Peer Reviewed
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[Journal Article] Metalloproteinase inhibition has differential effects on alloimmunity, autoimmunity, and histopathology in the transplanted lung2007
Author(s)
Yoshida S, Iwata T, Chiyo M, Smith GN, Foresman B, Mickler E, Heidler KM, Cummings OW, Fujisawa T, Brand DD, Baker A, Wilkes DS
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Journal Title
Transplantation Vol 83
Pages: 799-808
Peer Reviewed
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